Pantoprazole and Optic neuropathy - a phase IV clinical study of FDA data

Summary:

Optic neuropathy is reported as a side effect among people who take Pantoprazole (pantoprazole sodium), especially for people who are female, 60+ old, also take Prednisone, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Optic neuropathy when taking Pantoprazole. It is created by eHealthMe based on reports of 281,696 people who have side effects when taking Pantoprazole from the FDA, and is updated regularly.

What is Pantoprazole?

Pantoprazole has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 285,167 Pantoprazole users. Check the latest studies of Pantoprazole.

What is Optic neuropathy?

Optic neuropathy (optic nerve damage) is found to be associated with 258 drugs and 452 conditions by eHealthMe. Check the latest studies of Optic neuropathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

281,696 people reported to have side effects when taking Pantoprazole.
Among them, 37 people (0.01%) have Optic neuropathy.

Could Pantoprazole cause Optic neuropathy?

Among these 37 people:

What is the gender of people who have Optic neuropathy when taking Pantoprazole? *

female: 52.78 %
male: 47.22 %

What is the age of people who have Optic neuropathy when taking Pantoprazole? *

What are other drugs people take besides Pantoprazole? *

What are other side effects people have besides Optic neuropathy? *

Papilloedema (optic disc swelling): 11 people, 29.73%
Vision Blurred: 6 people, 16.22%
Optic Atrophy (the loss of a proportion of optic disc nerve fibres): 5 people, 13.51%
Blindness: 5 people, 13.51%
Halo Vision (rainbow vision): 5 people, 13.51%
Visual Acuity Reduced (reduced clearness of vision): 5 people, 13.51%
Corneal Deposits: 4 people, 10.81%
Visual Field Defect: 4 people, 10.81%
Intraocular Pressure Increased: 3 people, 8.11%
Lactic Acidosis (low ph in body tissues): 3 people, 8.11%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 18.92%
Pain: 5 people, 13.51%
Constipation: 5 people, 13.51%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 5 people, 13.51%
Osteoporosis (bones weak and more likely to break): 5 people, 13.51%
High Blood Pressure: 4 people, 10.81%
Rashes (redness): 4 people, 10.81%
Staphylococcal Infection (an infection with staphylococcus bacteria): 3 people, 8.11%
Arrhythmias (irregular heartbeat): 2 people, 5.41%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Pantoprazole and have Optic neuropathy?

- Check whether Optic neuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pantoprazole:

Pantoprazole (285,167 reports)

Browse all side effects of Pantoprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Optic neuropathy:

Optic neuropathy (258 drugs)

Browse all the conditions that are associated with Optic neuropathy:

Optic neuropathy (452 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Pantoprazole) and Pantoprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.