Paracaine and Glaucoma - a phase IV clinical study of FDA data

Summary:

Glaucoma is reported as a side effect among people who take Paracaine (proparacaine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lucentis, and have Diabetic retinal oedema.

The phase IV clinical study analyzes which people have Glaucoma when taking Paracaine. It is created by eHealthMe based on reports of 669 people who have side effects when taking Paracaine from the FDA, and is updated regularly.

What is Paracaine?

Paracaine has active ingredients of proparacaine hydrochloride. eHealthMe is studying from 673 Paracaine users. Check the latest studies of Paracaine.

What is Glaucoma?

Glaucoma (increased fluid pressure in the eye with vision loss) is found to be associated with 1,233 drugs and 1,657 conditions by eHealthMe. Check the latest studies of Glaucoma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

669 people reported to have side effects when taking Paracaine.
Among them, 14 people (2.09%) have Glaucoma.

Among these 14 people:

How long have people been on Paracaine when they have Glaucoma? *

What is the gender of people who have Glaucoma when taking Paracaine? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Glaucoma when taking Paracaine? *

What are other drugs people take besides Paracaine? *

What are other side effects people have besides Glaucoma? *

Visual Acuity Reduced (reduced clearness of vision): 7 people, 50.00%
Vision Blurred: 5 people, 35.71%
Vitreous Detachment (a condition of the eye in which the vitreous humour separates from the retina): 4 people, 28.57%
Disease Progression: 3 people, 21.43%
Foreign Body Sensation In Eyes (feeling of something in eye): 3 people, 21.43%
Retinal Disorder (disease of retina): 3 people, 21.43%
Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 3 people, 21.43%
Cataract (clouding of the lens inside the eye): 3 people, 21.43%
Visual Impairment: 3 people, 21.43%
Keratopathy (noninflammatory disease of the cornea): 2 people, 14.29%

What are the existing conditions these people have? *

Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 4 people, 28.57%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 3 people, 21.43%
Anaesthesia: 3 people, 21.43%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 2 people, 14.29%
Retinal Oedema (swelling of retina): 2 people, 14.29%
Multiple Myeloma (cancer of the plasma cells): 2 people, 14.29%
Age-Related Macular Degeneration: 2 people, 14.29%
Retinal Telangiectasia (a disease affecting the macula, causing loss of central vision. the macula is a small area in the retina): 1 person, 7.14%
Pain: 1 person, 7.14%
Essential Hypertension (primary hypertension): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Paracaine and have Glaucoma?

- Check whether Glaucoma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paracaine:

Paracaine (673 reports)

Glaucoma treatments and more:

Glaucoma (61,927 reports)

Browse all side effects of Paracaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Glaucoma:

Glaucoma (1,233 drugs)

Browse all the conditions that are associated with Glaucoma:

Glaucoma (1,657 conditions)

Related publications that referenced our studies

Hu CY, Lee BJ, Cheng HF, Wang CY, "Acetazolamide-related life-threatening hypophosphatemia in a glaucoma patient", Journal of glaucoma, 2015 Apr .
Hu CY, Lee BJ, Cheng HF, Wang CY, "Acetazolamide-related life-threatening hypophosphatemia in a glaucoma patient", Journal of glaucoma, 2015 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on proparacaine hydrochloride (the active ingredients of Paracaine) and Paracaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.