Paracetamol and Hyperpyrexia - a phase IV clinical study of FDA data

Summary:

Hyperpyrexia is reported as a side effect among people who take Paracetamol (acetaminophen), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Morphine, and have High blood pressure.

The phase IV clinical study analyzes which people have Hyperpyrexia when taking Paracetamol. It is created by eHealthMe based on reports of 114,713 people who have side effects when taking Paracetamol from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Hyperpyrexia?

Hyperpyrexia (extremely high fever) is found to be associated with 373 drugs and 528 conditions by eHealthMe. Check the latest studies of Hyperpyrexia.

On Aug, 01, 2026

114,713 people reported to have side effects when taking Paracetamol.
Among them, 118 people (0.1%) have Hyperpyrexia.

Among these 118 people:

* Approximation only. Some reports may have incomplete information.

Do you take Paracetamol and have Hyperpyrexia?

- Check whether Hyperpyrexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paracetamol:

Paracetamol (115,650 reports)

Hyperpyrexia treatments and more:

Hyperpyrexia (4,941 reports)

How severe was Hyperpyrexia and when was it recovered:

Hyperpyrexia in Paracetamol

Expand to all the drugs that have ingredients of acetaminophen:

Hyperpyrexia and drugs with ingredients of acetaminophen (244 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Paracetamol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperpyrexia:

Hyperpyrexia (373 drugs)

Browse all the conditions that are associated with Hyperpyrexia:

Hyperpyrexia (528 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Paracetamol) and Paracetamol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.