Paxil and Rebound effect - a phase IV clinical study of FDA data

Summary:

Rebound effect is reported as a side effect among people who take Paxil (paroxetine hydrochloride), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Buspar, and have Back pain.

The phase IV clinical study analyzes which people have Rebound effect when taking Paxil. It is created by eHealthMe based on reports of 88,676 people who have side effects when taking Paxil from the FDA, and is updated regularly.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

What is Rebound effect?

Rebound effect (take-back effect) is found to be associated with 371 drugs and 567 conditions by eHealthMe. Check the latest studies of Rebound effect.

On Jul, 15, 2026

88,676 people reported to have side effects when taking Paxil.
Among them, 25 people (0.03%) have Rebound effect.

Among these 25 people:

How long have people been on Paxil when they have Rebound effect? *

What is the gender of people who have Rebound effect when taking Paxil? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Rebound effect when taking Paxil? *

What are other drugs people take besides Paxil? *

What are other side effects people have besides Rebound effect? *

Drug Dependence: 11 people, 44.00%
Nausea (feeling of having an urge to vomit): 8 people, 32.00%
Abdominal Pain: 8 people, 32.00%
Dizziness: 8 people, 32.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 8 people, 32.00%
Insomnia (sleeplessness): 8 people, 32.00%
Influenza Like Illness: 7 people, 28.00%
Muscle Aches (muscle pain): 7 people, 28.00%
Nightmares (unpleasant dreams): 7 people, 28.00%
Panic Disorder: 7 people, 28.00%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 8.00%
Panic Disorder: 2 people, 8.00%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 8.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.00%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 8.00%
Back Pain: 2 people, 8.00%
Post-Traumatic Stress Disorder: 1 person, 4.00%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 4.00%
Borderline Personality Disorder: 1 person, 4.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Paxil and have Rebound effect?

- Check whether Rebound effect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paxil:

Paxil (92,546 reports)

Rebound effect treatments and more:

Rebound effect (8,859 reports)

Browse all side effects of Paxil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rebound effect:

Rebound effect (371 drugs)

Browse all the conditions that are associated with Rebound effect:

Rebound effect (567 conditions)

Related publications that referenced our studies

Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on paroxetine hydrochloride (the active ingredients of Paxil) and Paxil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.