Paxlovid and Toothaches - a phase IV clinical study of FDA data

Summary:

Toothaches is reported as a side effect among people who take Paxlovid (nirmatrelvir; ritonavir), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Amlodipine, and have High blood pressure.

The phase IV clinical study analyzes which people have Toothaches when taking Paxlovid. It is created by eHealthMe based on reports of 38,421 people who have side effects when taking Paxlovid from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,422 Paxlovid users. Check the latest studies of Paxlovid.

What is Toothaches?

Toothaches (tooth pain) is found to be associated with 1,318 drugs and 1,605 conditions by eHealthMe. Check the latest studies of Toothaches.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

38,421 people reported to have side effects when taking Paxlovid.
Among them, 33 people (0.09%) have Toothaches.

Among these 33 people:

How long have people been on Paxlovid when they have Toothaches? *

What is the gender of people who have Toothaches when taking Paxlovid? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Toothaches when taking Paxlovid? *

What are other drugs people take besides Paxlovid? *

What are other side effects people have besides Toothaches? *

Taste - Impaired: 9 people, 27.27%
Headache (pain in head): 7 people, 21.21%
Pain In Jaw: 6 people, 18.18%
Oral Pain: 5 people, 15.15%
Diarrhea: 5 people, 15.15%
Gingival Pain (gum pain): 5 people, 15.15%
Disease Recurrence: 5 people, 15.15%
Insomnia (sleeplessness): 5 people, 15.15%
Oral Discomfort (pain or irritation in mouth): 4 people, 12.12%
Nausea (feeling of having an urge to vomit): 4 people, 12.12%

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 12.12%
Stress And Anxiety: 1 person, 3.03%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 3.03%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 3.03%
Parkinson's Disease: 1 person, 3.03%
Pain: 1 person, 3.03%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 3.03%
High Blood Cholesterol: 1 person, 3.03%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 3.03%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Paxlovid and have Toothaches?

- Check whether Toothaches is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paxlovid:

Paxlovid (38,422 reports)

Toothaches treatments and more:

Toothaches (28,231 reports)

Browse all side effects of Paxlovid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toothaches:

Toothaches (1,318 drugs)

Browse all the conditions that are associated with Toothaches:

Toothaches (1,605 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nirmatrelvir; ritonavir (the active ingredients of Paxlovid) and Paxlovid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.