Pegasys and Large intestine perforation - a phase IV clinical study of FDA data

Summary:

Large intestine perforation is reported as a side effect among people who take Pegasys (peginterferon alfa 2a), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Intron A, and have Hiv infection.

The phase IV clinical study analyzes which people have Large intestine perforation when taking Pegasys. It is created by eHealthMe based on reports of 57,338 people who have side effects when taking Pegasys from the FDA, and is updated regularly.

What is Pegasys?

Pegasys has active ingredients of peginterferon alfa 2a. It is often used in hepatitis c. eHealthMe is studying from 57,446 Pegasys users. Check the latest studies of Pegasys.

What is Large intestine perforation?

Large intestine perforation (hole in large intestine) is found to be associated with 638 drugs and 794 conditions by eHealthMe. Check the latest studies of Large intestine perforation.

On Jul, 13, 2026

57,338 people reported to have side effects when taking Pegasys.
Among them, 23 people (0.04%) have Large intestine perforation.

Could Pegasys cause Large intestine perforation?

Among these 23 people:

How long have people been on Pegasys when they have Large intestine perforation? *

What is the gender of people who have Large intestine perforation when taking Pegasys? *

female: 9.52 %
male: 90.48 %

What is the age of people who have Large intestine perforation when taking Pegasys? *

What are other drugs people take besides Pegasys? *

Copegus: 12 people, 52.17%
Intron A: 12 people, 52.17%
Gabapentin: 10 people, 43.48%
Ribavirin: 9 people, 39.13%
Neupogen: 6 people, 26.09%
Rebetol: 5 people, 21.74%
Isentress: 3 people, 13.04%
Bupropion Hydrochloride: 3 people, 13.04%
Tramadol Hydrochloride: 2 people, 8.70%
Citalopram Hydrobromide: 2 people, 8.70%

What are other side effects people have besides Large intestine perforation? *

Peritoneal Adhesions: 13 people, 56.52%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 13 people, 56.52%
Intestinal Ischaemia (decreased supply of oxygenated blood to the intestines): 8 people, 34.78%
Collapse Of Lung (functional breakdown of lung): 7 people, 30.43%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 7 people, 30.43%
Abdominal Distension: 7 people, 30.43%
Scrotal Oedema (swelling of scrotum): 7 people, 30.43%
Skin Graft Failure (skin transplant failed): 7 people, 30.43%
Haematochezia (passage of stools containing blood): 6 people, 26.09%
Diarrhea: 6 people, 26.09%

What are the existing conditions these people have? *

Hiv Infection: 5 people, 21.74%
Pain: 1 person, 4.35%
Neutropenic Sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection): 1 person, 4.35%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 4.35%
Hepatitis C Virus Test Positive: 1 person, 4.35%
Depression: 1 person, 4.35%
Birth Control: 1 person, 4.35%
Anaemia (lack of blood): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Pegasys and have Large intestine perforation?

- Check whether Large intestine perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pegasys:

Pegasys (57,446 reports)

Browse all side effects of Pegasys:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Large intestine perforation:

Large intestine perforation (638 drugs)

Browse all the conditions that are associated with Large intestine perforation:

Large intestine perforation (794 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on peginterferon alfa 2a (the active ingredients of Pegasys) and Pegasys (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.