Pemetrexed disodium and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Pemetrexed disodium (pemetrexed disodium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Keytruda, and have Lung cancer - non-small cell.

The phase IV clinical study analyzes which people have Malaise when taking Pemetrexed disodium. It is created by eHealthMe based on reports of 4,269 people who have side effects when taking Pemetrexed disodium from the FDA, and is updated regularly.

What is Pemetrexed disodium?

Pemetrexed disodium has active ingredients of pemetrexed disodium. eHealthMe is studying from 4,270 Pemetrexed disodium users. Check the latest studies of Pemetrexed disodium.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,488 drugs and 5,129 conditions by eHealthMe. Check the latest studies of Malaise.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

4,269 people reported to have side effects when taking Pemetrexed disodium.
Among them, 69 people (1.62%) have Malaise.

Could Pemetrexed disodium cause Malaise?

Among these 69 people:

How long have people been on Pemetrexed disodium when they have Malaise? *

What is the gender of people who have Malaise when taking Pemetrexed disodium? *

female: 45.59 %
male: 54.41 %

What is the age of people who have Malaise when taking Pemetrexed disodium? *

What are other drugs people take besides Pemetrexed disodium? *

Keytruda: 41 people, 59.42%
Carboplatin: 27 people, 39.13%
Avastin: 7 people, 10.14%
Cisplatin: 7 people, 10.14%
Yervoy: 6 people, 8.70%
Opdivo: 6 people, 8.70%
Oxycodone Hydrochloride: 4 people, 5.80%
Folic Acid: 4 people, 5.80%
Metformin Hydrochloride: 3 people, 4.35%
Dexamethasone: 3 people, 4.35%

What are other side effects people have besides Malaise? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 17 people, 24.64%
Nausea (feeling of having an urge to vomit): 11 people, 15.94%
Pleural Effusion (water on the lungs): 10 people, 14.49%
Fever: 10 people, 14.49%
Anaemia (lack of blood): 9 people, 13.04%
Thrombocytopenia (decrease of platelets in blood): 9 people, 13.04%
Fatigue (feeling of tiredness): 9 people, 13.04%
Malignant Neoplasm Progression (cancer tumour came back): 8 people, 11.59%
Dyspnea (difficult or laboured breathing): 8 people, 11.59%
Blood Creatinine Increased: 7 people, 10.14%

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 26 people, 37.68%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 18 people, 26.09%
Lung Adenocarcinoma Stage Iv (the cancer has spread to other organs of the body, such as the other lung, brain, or liver): 7 people, 10.14%
Non-Small Cell Lung Cancer Recurrent (type of epithelial lung cancer reoccurrence): 6 people, 8.70%
High Blood Pressure: 5 people, 7.25%
Type 2 Diabetes: 4 people, 5.80%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.80%
Non-Small Cell Lung Cancer Stage Iv: 4 people, 5.80%
Interstitial Lung Disease: 3 people, 4.35%
Constipation: 3 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Pemetrexed disodium and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pemetrexed disodium:

Pemetrexed disodium (4,270 reports)

Malaise treatments and more:

Malaise (529,933 reports)

Browse all side effects of Pemetrexed disodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,488 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,129 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pemetrexed disodium (the active ingredients of Pemetrexed disodium) and Pemetrexed disodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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