Pemetrexed and Hyperkalemia - a phase IV clinical study of FDA data

Summary:

Hyperkalemia is reported as a side effect among people who take Pemetrexed (pemetrexed), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Cisplatin, and have Lung cancer - non-small cell.

The phase IV clinical study analyzes which people have Hyperkalemia when taking Pemetrexed. It is created by eHealthMe based on reports of 17,478 people who have side effects when taking Pemetrexed from the FDA, and is updated regularly.

What is Pemetrexed?

Pemetrexed has active ingredients of pemetrexed. eHealthMe is studying from 17,491 Pemetrexed users. Check the latest studies of Pemetrexed.

What is Hyperkalemia?

Hyperkalemia (damage to or disease of the kidney) is found to be associated with 1,951 drugs and 2,941 conditions by eHealthMe. Check the latest studies of Hyperkalemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 04, 2026

17,478 people reported to have side effects when taking Pemetrexed.
Among them, 62 people (0.35%) have Hyperkalemia.

Among these 62 people:

How long have people been on Pemetrexed when they have Hyperkalemia? *

What is the gender of people who have Hyperkalemia when taking Pemetrexed? *

female: 32.08 %
male: 67.92 %

What is the age of people who have Hyperkalemia when taking Pemetrexed? *

What are other drugs people take besides Pemetrexed? *

Cisplatin: 26 people, 41.94%
Folic Acid: 20 people, 32.26%
Dexamethasone: 13 people, 20.97%
Lactulose: 12 people, 19.35%
Acetaminophen: 7 people, 11.29%
Oxycontin: 7 people, 11.29%
Pantoprazole: 7 people, 11.29%
Metoclopramide Hydrochloride: 6 people, 9.68%
Mirtazapine: 6 people, 9.68%
Vitamin E: 6 people, 9.68%

What are other side effects people have besides Hyperkalemia? *

Nausea (feeling of having an urge to vomit): 18 people, 29.03%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 16 people, 25.81%
Blood Creatinine Increased: 13 people, 20.97%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 13 people, 20.97%
White Blood Cell Count Decreased: 12 people, 19.35%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 11 people, 17.74%
Anaemia (lack of blood): 10 people, 16.13%
Thrombocytopenia (decrease of platelets in blood): 9 people, 14.52%
Fatigue (feeling of tiredness): 8 people, 12.90%
Dyspnea (difficult or laboured breathing): 7 people, 11.29%

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 29 people, 46.77%
High Blood Pressure: 7 people, 11.29%
Diabetes: 7 people, 11.29%
Mesothelioma Malignant (cancer that occurs in the thin layer of cells lining the body's internal organs, known as the mesothelium): 6 people, 9.68%
Cancer Pain: 6 people, 9.68%
Pleural Mesothelioma Malignant (cancer of the pleura, or the membrane that lines the lungs): 5 people, 8.06%
Gastritis (inflammation of stomach): 5 people, 8.06%
Pain: 5 people, 8.06%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 5 people, 8.06%
Constipation: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Pemetrexed and have Hyperkalemia?

- Check whether Hyperkalemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pemetrexed:

Pemetrexed (17,491 reports)

Hyperkalemia treatments and more:

Hyperkalemia (78,085 reports)

Browse all side effects of Pemetrexed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkalemia:

Hyperkalemia (1,951 drugs)

Browse all the conditions that are associated with Hyperkalemia:

Hyperkalemia (2,941 conditions)

Related publications that referenced our studies

Gota V, Kavathiya K, Doshi K, Gurjar M, Damodaran SE, Noronha V, Joshi A, Prabhash K, "High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy", Cancer management and research, 2017 Jan .
Gota V, Kavathiya K, Doshi K, Gurjar M, Damodaran SE, Noronha V, Joshi A, Prabhash K, "High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy", Cancer management and research, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on pemetrexed (the active ingredients of Pemetrexed) and Pemetrexed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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