Pennsaid and Application site exfoliation - a phase IV clinical study of FDA data

Summary:

Application site exfoliation is reported as a side effect among people who take Pennsaid (diclofenac sodium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Vitamin C, and have Osteoarthritis.

The phase IV clinical study analyzes which people have Application site exfoliation when taking Pennsaid. It is created by eHealthMe based on reports of 2,824 people who have side effects when taking Pennsaid from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Application site exfoliation?

Application site exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface) is found to be associated with 178 drugs and 352 conditions by eHealthMe. Check the latest studies of Application site exfoliation.

On Jul, 19, 2026

2,824 people reported to have side effects when taking Pennsaid.
Among them, 63 people (2.23%) have Application site exfoliation.

Could Pennsaid cause Application site exfoliation?

Among these 63 people:

How long have people been on Pennsaid when they have Application site exfoliation? *

What is the gender of people who have Application site exfoliation when taking Pennsaid? *

female: 49.15 %
male: 50.85 %

What is the age of people who have Application site exfoliation when taking Pennsaid? *

What are other drugs people take besides Pennsaid? *

What are other side effects people have besides Application site exfoliation? *

Application Site Erythema (redness of the skin at application site): 15 people, 23.81%
Application Site Dryness: 14 people, 22.22%
Application Site Pruritus (application site severe itching of the skin): 11 people, 17.46%
Application Site Pain: 9 people, 14.29%
Application Site Rash: 7 people, 11.11%
Dry Skin: 5 people, 7.94%
Application Site Vesicles (small bubble within a cell at application site): 4 people, 6.35%
Application Site Swelling: 4 people, 6.35%
Drug Ineffective: 3 people, 4.76%
Itching: 2 people, 3.17%

What are the existing conditions these people have? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 14 people, 22.22%
Joint Pain: 11 people, 17.46%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 9.52%
Pain In Extremity: 5 people, 7.94%
Epicondylitis (tennis elbow): 4 people, 6.35%
Tendonitis (a condition that causes pain and swelling of tendons): 2 people, 3.17%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 3.17%
Inflammation: 2 people, 3.17%
Exostosis (formation of new bone on the surface of a bone): 1 person, 1.59%
Gouty Arthritis (joint inflammation with crystal formation): 1 person, 1.59%

* Approximation only. Some reports may have incomplete information.

Do you take Pennsaid and have Application site exfoliation?

- Check whether Application site exfoliation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pennsaid:

Pennsaid (2,849 reports)

Browse all side effects of Pennsaid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site exfoliation:

Application site exfoliation (178 drugs)

Browse all the conditions that are associated with Application site exfoliation:

Application site exfoliation (352 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium (the active ingredients of Pennsaid) and Pennsaid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.