Pennsaid and Heart attack - a phase IV clinical study of FDA data

Summary:

Heart attack is reported as a side effect among people who take Pennsaid (diclofenac sodium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Norco, and have Diabetes.

The phase IV clinical study analyzes which people have Heart attack when taking Pennsaid. It is created by eHealthMe based on reports of 2,824 people who have side effects when taking Pennsaid from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Heart attack?

Heart attack is found to be associated with 2,484 drugs and 3,296 conditions by eHealthMe. Check the latest studies of Heart attack.

On Jul, 14, 2026

2,824 people reported to have side effects when taking Pennsaid.
Among them, 11 people (0.39%) have Heart attack.

Among these 11 people:

How long have people been on Pennsaid when they have Heart attack? *

What is the gender of people who have Heart attack when taking Pennsaid? *

female: 30 %
male: 70 %

What is the age of people who have Heart attack when taking Pennsaid? *

What are other drugs people take besides Pennsaid? *

Zetia: 2 people, 18.18%
Voltaren: 2 people, 18.18%
Norco: 2 people, 18.18%
Carfilzomib: 1 person, 9.09%
Inderal: 1 person, 9.09%
Hydrocodone Bitartrate And Acetaminophen: 1 person, 9.09%
Humira: 1 person, 9.09%
Hctz: 1 person, 9.09%
Glucovance: 1 person, 9.09%
Esbriet: 1 person, 9.09%

What are other side effects people have besides Heart attack? *

Cardiac Disorder: 2 people, 18.18%
Weakness: 1 person, 9.09%
Dyspnea (difficult or laboured breathing): 1 person, 9.09%
Aortic Valve Disease: 1 person, 9.09%
Application Site Reaction: 1 person, 9.09%
Arrhythmias (irregular heartbeat): 1 person, 9.09%
Blood Test Abnormal: 1 person, 9.09%
Bundle Branch Block (disruption in the normal flow of electrical pulses that drive the heart beat): 1 person, 9.09%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 1 person, 9.09%
Carotid Artery Occlusion (artery blockage): 1 person, 9.09%

What are the existing conditions these people have? *

Pain: 2 people, 18.18%
Diabetes: 2 people, 18.18%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 9.09%
Indigestion: 1 person, 9.09%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 9.09%
Back Pain: 1 person, 9.09%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 1 person, 9.09%
Constipation: 1 person, 9.09%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 9.09%
Electrocardiogram Abnormal: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Pennsaid and have Heart attack?

- Check whether Heart attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pennsaid:

Pennsaid (2,849 reports)

Heart attack treatments and more:

Heart attack (266,145 reports)

Browse all side effects of Pennsaid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart attack:

Heart attack (2,484 drugs)

Browse all the conditions that are associated with Heart attack:

Heart attack (3,296 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium (the active ingredients of Pennsaid) and Pennsaid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.