Pentasa and Irritable bowel syndrome - a phase IV clinical study of FDA data

Summary:

Irritable bowel syndrome is reported as a side effect among people who take Pentasa (mesalamine), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Vitamin B12, and have Pain.

The phase IV clinical study analyzes which people have Irritable bowel syndrome when taking Pentasa. It is created by eHealthMe based on reports of 22,797 people who have side effects when taking Pentasa from the FDA, and is updated regularly.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

What is Irritable bowel syndrome?

Irritable bowel syndrome is found to be associated with 1,315 drugs and 2,128 conditions by eHealthMe. Check the latest studies of Irritable bowel syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

22,797 people reported to have side effects when taking Pentasa.
Among them, 65 people (0.29%) have Irritable bowel syndrome.

Could Pentasa cause Irritable bowel syndrome?

Among these 65 people:

How long have people been on Pentasa when they have Irritable bowel syndrome? *

What is the gender of people who have Irritable bowel syndrome when taking Pentasa? *

female: 68.97 %
male: 31.03 %

What is the age of people who have Irritable bowel syndrome when taking Pentasa? *

What are other drugs people take besides Pentasa? *

What are other side effects people have besides Irritable bowel syndrome? *

Diarrhea: 24 people, 36.92%
Pain: 22 people, 33.85%
Stress And Anxiety: 21 people, 32.31%
Headache (pain in head): 20 people, 30.77%
Malaise (a feeling of general discomfort or uneasiness): 20 people, 30.77%
Nausea (feeling of having an urge to vomit): 20 people, 30.77%
Weight Decreased: 19 people, 29.23%
Back Pain: 19 people, 29.23%
Sinusitis (inflammation of sinus): 19 people, 29.23%
Flatulence (flatus expelled through the anus): 19 people, 29.23%

What are the existing conditions these people have? *

Pain: 12 people, 18.46%
High Blood Cholesterol: 7 people, 10.77%
High Blood Pressure: 6 people, 9.23%
Diarrhea: 5 people, 7.69%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 6.15%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 6.15%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 4 people, 6.15%
Acne (skin problems that cause pimples): 3 people, 4.62%
Hypersensitivity: 3 people, 4.62%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 4.62%

* Approximation only. Some reports may have incomplete information.

Do you take Pentasa and have Irritable bowel syndrome?

- Check whether Irritable bowel syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pentasa:

Pentasa (23,325 reports)

Browse all side effects of Pentasa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritable bowel syndrome:

Irritable bowel syndrome (1,315 drugs)

Browse all the conditions that are associated with Irritable bowel syndrome:

Irritable bowel syndrome (2,128 conditions)

Related publications that referenced our studies

Jacobsson H, Eriksen J, Karlén P, "Mesalazine-induced renal calculi", The American journal of case reports, 2015 Jan .
Jacobsson H, Eriksen J, Karlén P, "Mesalazine-induced renal calculi", The American journal of case reports, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on mesalamine (the active ingredients of Pentasa) and Pentasa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.