Pepcid and Gastric perforation - a phase IV clinical study of FDA data

Summary:

Gastric perforation is reported as a side effect among people who take Pepcid (famotidine), especially for people who are male, 0-1 old, have been taking the drug for < 1 month also take Indocin, and have Abdominal discomfort.

The phase IV clinical study analyzes which people have Gastric perforation when taking Pepcid. It is created by eHealthMe based on reports of 54,527 people who have side effects when taking Pepcid from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

What is Gastric perforation?

Gastric perforation (hole in stomach) is found to be associated with 303 drugs and 429 conditions by eHealthMe. Check the latest studies of Gastric perforation.

On Jul, 14, 2026

54,527 people reported to have side effects when taking Pepcid.
Among them, 17 people (0.03%) have Gastric perforation.

Among these 17 people:

How long have people been on Pepcid when they have Gastric perforation? *

What is the gender of people who have Gastric perforation when taking Pepcid? *

female: 25 %
male: 75 %

What is the age of people who have Gastric perforation when taking Pepcid? *

What are other drugs people take besides Pepcid? *

Indocin: 4 people, 23.53%
Zofran: 3 people, 17.65%
Aminophylline: 3 people, 17.65%
Furosemide: 3 people, 17.65%
Dilaudid: 1 person, 5.88%
Epipen: 1 person, 5.88%
Epinephrine: 1 person, 5.88%
Emend: 1 person, 5.88%
Diphenhydramine Hydrochloride: 1 person, 5.88%
Decadron: 1 person, 5.88%

What are other side effects people have besides Gastric perforation? *

Gastric Haemorrhage (bleeding stomach): 7 people, 41.18%
Haematemesis (vomiting of blood): 7 people, 41.18%
Gastric Cancer (stomach cancer): 4 people, 23.53%
Necrotizing Enterocolitis Neonatal (portions of the bowel undergo necrosis (tissue death)): 4 people, 23.53%
Abdominal Distension: 4 people, 23.53%
Hyperkalemia (damage to or disease of the kidney): 3 people, 17.65%
Platelet Count Abnormal: 3 people, 17.65%
Leukopenia (less number of white blood cells in blood): 3 people, 17.65%
Anaemia (lack of blood): 3 people, 17.65%
C-Reactive Protein Increased: 3 people, 17.65%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
Osteoporosis (bones weak and more likely to break): 1 person, 5.88%
Neoplasm Malignant (cancer tumour): 1 person, 5.88%
Immune System Disorder: 1 person, 5.88%
Hypersensitivity: 1 person, 5.88%
Goodpasture's Syndrome (immune system mistakenly attacks and destroys healthy body tissue): 1 person, 5.88%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 1 person, 5.88%
B-Cell Type Acute Leukaemia (cancer of the white blood cells): 1 person, 5.88%
Abdominal Pain Upper: 1 person, 5.88%
Abdominal Discomfort: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Pepcid and have Gastric perforation?

- Check whether Gastric perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pepcid:

Pepcid (55,774 reports)

Browse all side effects of Pepcid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastric perforation:

Gastric perforation (303 drugs)

Browse all the conditions that are associated with Gastric perforation:

Gastric perforation (429 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on famotidine (the active ingredients of Pepcid) and Pepcid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.