Pepcid and Oa - a phase IV clinical study of FDA data

Summary:

Oa is reported as a side effect among people who take Pepcid (famotidine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Oa when taking Pepcid. It is created by eHealthMe based on reports of 54,527 people who have side effects when taking Pepcid from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,770 Pepcid users. Check the latest studies of Pepcid.

What is Oa?

Oa (osteoarthritis /a joint disease caused by cartilage loss in a joint) is found to be associated with 1,903 drugs and 2,628 conditions by eHealthMe. Check the latest studies of Oa.

On Jan, 10, 2026

54,527 people reported to have side effects when taking Pepcid.
Among them, 569 people (1.04%) have Oa.

Among these 569 people:

* Approximation only. Some reports may have incomplete information.

Do you take Pepcid and have Oa?

- Check whether Oa is associated with a drug or a condition (FREE)
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pepcid:

Pepcid (55,770 reports)

Oa treatments and more:

Oa (95,648 reports)

How severe was Oa and when was it recovered:

Oa in Pepcid

Expand to all the drugs that have ingredients of famotidine:

Oa and drugs with ingredients of famotidine (1,036 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Pepcid side effects:

Browse all side effects of Pepcid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Oa:

Humira side effect: Oa (11,504 reports)
Methotrexate side effect: Oa (9,966 reports)
Fosamax side effect: Oa (9,637 reports)
Prednisone side effect: Oa (7,262 reports)
Enbrel side effect: Oa (6,608 reports)
Aspirin side effect: Oa (4,218 reports)
Xeljanz side effect: Oa (4,009 reports)
Sulfasalazine side effect: Oa (3,805 reports)
Alendronate sodium side effect: Oa (3,694 reports)
Celebrex side effect: Oa (3,551 reports)

Browse all the drugs that are associated with Oa:

Oa (1,903 drugs)

Common conditions associated with Oa:

Browse all the conditions that are associated with Oa:

Oa (2,628 conditions)

Drugs similar to Pepcid and Oa :

How the study uses the data?

The study uses data from the FDA. It is based on famotidine (the active ingredients of Pepcid) and Pepcid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.