Periactin and Stroke - a phase IV clinical study of FDA data

Summary:

Stroke is reported as a side effect among people who take Periactin (cyproheptadine hydrochloride), especially for people who are female, 60+ old, also take Protonix, and have High blood pressure.

The phase IV clinical study analyzes which people have Stroke when taking Periactin. It is created by eHealthMe based on reports of 2,086 people who have side effects when taking Periactin from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 2,365 drugs and 3,014 conditions by eHealthMe. Check the latest studies of Stroke.

On Jan, 19, 2026

2,086 people reported to have side effects when taking Periactin.
Among them, 18 people (0.86%) have Stroke.

Among these 18 people:

What is the gender of people who have Stroke when taking Periactin? *

female: 72.22 %
male: 27.78 %

What is the age of people who have Stroke when taking Periactin? *

What are other drugs people take besides Periactin? *

What are other side effects people have besides Stroke? *

Weakness: 7 people, 38.89%
Hypersensitivity: 7 people, 38.89%
Organ Failure: 6 people, 33.33%
Pharyngeal Oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal): 6 people, 33.33%
Hypotension (abnormally low blood pressure): 6 people, 33.33%
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 5 people, 27.78%
Heart Rate Increased: 5 people, 27.78%
Nausea (feeling of having an urge to vomit): 5 people, 27.78%
Mouth Haemorrhage (bleeding from mouth): 5 people, 27.78%
Overdose: 5 people, 27.78%

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 27.78%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Stress And Anxiety: 2 people, 11.11%
Pain: 2 people, 11.11%
Nausea (feeling of having an urge to vomit): 2 people, 11.11%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 2 people, 11.11%
Urinary Tract Infection: 2 people, 11.11%
Depression: 2 people, 11.11%
Adrenal Disorder: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Periactin and have Stroke?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Periactin:

Periactin (2,214 reports)

Stroke treatments and more:

Stroke (334,632 reports)

Browse all side effects of Periactin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke:

Stroke (2,365 drugs)

Browse all the conditions that are associated with Stroke:

Stroke (3,014 conditions)

Drugs similar to Periactin and Stroke :

How the study uses the data?

The study uses data from the FDA. It is based on cyproheptadine hydrochloride (the active ingredients of Periactin) and Periactin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.