Peridex and Encephalopathy - a phase IV clinical study of FDA data

Summary:

Encephalopathy is reported as a side effect among people who take Peridex (chlorhexidine gluconate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vancomycin, and have High blood pressure.

The phase IV clinical study analyzes which people have Encephalopathy when taking Peridex. It is created by eHealthMe based on reports of 2,787 people who have side effects when taking Peridex from the FDA, and is updated regularly.

What is Peridex?

Peridex has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 2,803 Peridex users. Check the latest studies of Peridex.

What is Encephalopathy?

Encephalopathy (functioning of the brain is affected by some agent or condition) is found to be associated with 1,459 drugs and 1,607 conditions by eHealthMe. Check the latest studies of Encephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

2,787 people reported to have side effects when taking Peridex.
Among them, 47 people (1.69%) have Encephalopathy.

Among these 47 people:

How long have people been on Peridex when they have Encephalopathy? *

What is the gender of people who have Encephalopathy when taking Peridex? *

female: 61.7 %
male: 38.3 %

What is the age of people who have Encephalopathy when taking Peridex? *

What are other drugs people take besides Peridex? *

What are other side effects people have besides Encephalopathy? *

Pain: 23 people, 48.94%
Hypotension (abnormally low blood pressure): 21 people, 44.68%
Osteonecrosis Of Jaw (death of bone of jaw): 21 people, 44.68%
Pneumonia: 20 people, 42.55%
Spinal Osteoarthritis (joint cartilage loss in spine): 20 people, 42.55%
Diarrhea: 19 people, 40.43%
Pain In Jaw: 18 people, 38.30%
Osteomyelitis (infection of bone): 17 people, 36.17%
Pleural Effusion (water on the lungs): 17 people, 36.17%
Sepsis (a severe blood infection that can lead to organ failure and death): 17 people, 36.17%

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 25.53%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 9 people, 19.15%
Osteoporosis (bones weak and more likely to break): 8 people, 17.02%
Nausea (feeling of having an urge to vomit): 6 people, 12.77%
Insomnia (sleeplessness): 6 people, 12.77%
Constipation: 6 people, 12.77%
Hepatic Neoplasm Malignant (liver cancer): 6 people, 12.77%
Pain: 6 people, 12.77%
Diarrhea: 6 people, 12.77%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 6 people, 12.77%

* Approximation only. Some reports may have incomplete information.

Do you take Peridex and have Encephalopathy?

- Check whether Encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Peridex:

Peridex (2,803 reports)

Encephalopathy treatments and more:

Encephalopathy (27,832 reports)

Browse all side effects of Peridex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Encephalopathy:

Encephalopathy (1,459 drugs)

Browse all the conditions that are associated with Encephalopathy:

Encephalopathy (1,607 conditions)

Related publications that referenced our studies

Kapoor A, Kumar V, Beniwal S, Dutta S, Goyal S, Kumar HS, "Posterior reversible encephalopathy syndrome in non-Hodgkin's lymphoma: Not necessarily reversible!", Clinical Cancer Investigation Journal, 2015 Mar .
Kapoor A, Kumar V, Beniwal S, Dutta S, Goyal S, Kumar HS, "Posterior reversible encephalopathy syndrome in non-Hodgkin's lymphoma: Not necessarily reversible!", Clinical Cancer Investigation Journal, 2015 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on chlorhexidine gluconate (the active ingredients of Peridex) and Peridex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.