Permax and Tricuspid valve incompetence - a phase IV clinical study of FDA data

Summary:

Tricuspid valve incompetence is reported as a side effect among people who take Permax (pergolide mesylate), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Sinemet, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Tricuspid valve incompetence when taking Permax. It is created by eHealthMe based on reports of 1,529 people who have side effects when taking Permax from the FDA, and is updated regularly.

What is Permax?

Permax has active ingredients of pergolide mesylate. eHealthMe is studying from 1,532 Permax users. Check the latest studies of Permax.

What is Tricuspid valve incompetence?

Tricuspid valve incompetence (inefficient heart valve) is found to be associated with 1,198 drugs and 1,196 conditions by eHealthMe. Check the latest studies of Tricuspid valve incompetence.

On Jul, 25, 2026

1,529 people reported to have side effects when taking Permax.
Among them, 82 people (5.36%) have Tricuspid valve incompetence.

Could Permax cause Tricuspid valve incompetence?

Among these 82 people:

How long have people been on Permax when they have Tricuspid valve incompetence? *

What is the gender of people who have Tricuspid valve incompetence when taking Permax? *

female: 65.85 %
male: 34.15 %

What is the age of people who have Tricuspid valve incompetence when taking Permax? *

What are other drugs people take besides Permax? *

Sinemet: 28 people, 34.15%
Artane: 10 people, 12.20%
Comtan: 9 people, 10.98%
Cabergoline: 8 people, 9.76%
Pramipexole Dihydrochloride: 8 people, 9.76%
Lasix: 7 people, 8.54%
Carbidopa And Levodopa: 7 people, 8.54%
Vioxx: 7 people, 8.54%
Zoloft: 6 people, 7.32%
Clonazepam: 6 people, 7.32%

What are other side effects people have besides Tricuspid valve incompetence? *

Mitral Valve Incompetence (inefficient heart valve): 65 people, 79.27%
Aortic Valve Incompetence: 53 people, 64.63%
Oedema Peripheral (superficial swelling): 28 people, 34.15%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 22 people, 26.83%
Pleural Effusion (water on the lungs): 21 people, 25.61%
Cardiac Valve Disease (heart valve disease): 19 people, 23.17%
Cardiac Murmur (an heart sound in valve abnormality): 15 people, 18.29%
Dyspnea (difficult or laboured breathing): 15 people, 18.29%
Cardiac Failure Congestive: 14 people, 17.07%
Chest Pain: 14 people, 17.07%

What are the existing conditions these people have? *

Parkinson's Disease: 57 people, 69.51%
Restless Leg Syndrome (a powerful urge to move your legs): 7 people, 8.54%
Muscle Twitching: 3 people, 3.66%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 1.22%
Rheumatic Fever (an inflammatory disease that occurs following a streptococcus pyogenes infection): 1 person, 1.22%
Depression: 1 person, 1.22%

* Approximation only. Some reports may have incomplete information.

Do you take Permax and have Tricuspid valve incompetence?

- Check whether Tricuspid valve incompetence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Permax:

Permax (1,532 reports)

Browse all side effects of Permax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tricuspid valve incompetence:

Tricuspid valve incompetence (1,198 drugs)

Browse all the conditions that are associated with Tricuspid valve incompetence:

Tricuspid valve incompetence (1,196 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pergolide mesylate (the active ingredients of Permax) and Permax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.