Pioglitazone and Ulcerative colitis - a phase IV clinical study of FDA data

Summary:

Ulcerative colitis is reported as a side effect among people who take Pioglitazone (pioglitazone hydrochloride), especially for people who are female, 60+ old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Ulcerative colitis when taking Pioglitazone. It is created by eHealthMe based on reports of 12,725 people who have side effects when taking Pioglitazone from the FDA, and is updated regularly.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

What is Ulcerative colitis?

Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine) is found to be associated with 1,200 drugs and 2,051 conditions by eHealthMe. Check the latest studies of Ulcerative colitis.

On Jul, 15, 2026

12,725 people reported to have side effects when taking Pioglitazone.
Among them, 11 people (0.09%) have Ulcerative colitis.

Could Pioglitazone cause Ulcerative colitis?

Among these 11 people:

What is the gender of people who have Ulcerative colitis when taking Pioglitazone? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Ulcerative colitis when taking Pioglitazone? *

What are other drugs people take besides Pioglitazone? *

What are other side effects people have besides Ulcerative colitis? *

Blood Glucose Increased: 4 people, 36.36%
The Flu (the flu is caused by an influenza virus): 2 people, 18.18%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 2 people, 18.18%
Dehydration (dryness resulting from the removal of water): 2 people, 18.18%
Benign Neoplasm Of Skin (benign (non-cancerous) tumours of the skin): 2 people, 18.18%
Pelvic Discomfort: 2 people, 18.18%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 18.18%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 18.18%
Lipoma (a growth of fatty tissue that slowly develops just under your skin): 2 people, 18.18%
Weight Decreased: 1 person, 9.09%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 27.27%
Pain: 2 people, 18.18%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 18.18%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 2 people, 18.18%
Dyslipidaemia (abnormal amount of lipids): 2 people, 18.18%
Depression: 2 people, 18.18%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 18.18%
Stable Angina (a constant chest pain): 1 person, 9.09%
Seasonal Allergy (allergic condition due to certain season): 1 person, 9.09%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Pioglitazone and have Ulcerative colitis?

- Check whether Ulcerative colitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pioglitazone:

Pioglitazone (12,864 reports)

Browse all side effects of Pioglitazone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ulcerative colitis:

Ulcerative colitis (1,200 drugs)

Browse all the conditions that are associated with Ulcerative colitis:

Ulcerative colitis (2,051 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Pioglitazone) and Pioglitazone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.