Plaquenil and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Plaquenil (hydroxychloroquine sulfate), especially for people who are female, 60+ old, also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Anhedonia when taking Plaquenil. It is created by eHealthMe based on reports of 88,348 people who have side effects when taking Plaquenil from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,506 drugs and 1,284 conditions by eHealthMe. Check the latest studies of Anhedonia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

88,348 people reported to have side effects when taking Plaquenil.
Among them, 88 people (0.1%) have Anhedonia.

Among these 88 people:

What is the gender of people who have Anhedonia when taking Plaquenil? *

female: 63.22 %
male: 36.78 %

What is the age of people who have Anhedonia when taking Plaquenil? *

What are other drugs people take besides Plaquenil? *

What are other side effects people have besides Anhedonia? *

Pain: 86 people, 97.73%
Stress And Anxiety: 81 people, 92.05%
Injury: 57 people, 64.77%
Emotional Distress: 55 people, 62.50%
Depression: 44 people, 50.00%
Weakness: 35 people, 39.77%
Joint Pain: 32 people, 36.36%
Pneumonia: 30 people, 34.09%
Osteonecrosis Of Jaw (death of bone of jaw): 30 people, 34.09%
Neuropathy Peripheral (surface nerve damage): 30 people, 34.09%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 19 people, 21.59%
Pain: 11 people, 12.50%
High Blood Pressure: 8 people, 9.09%
Neoplasm Malignant (cancer tumour): 8 people, 9.09%
Hiv Infection: 7 people, 7.95%
Nuclear Magnetic Resonance Imaging Brain: 7 people, 7.95%
Anaemia (lack of blood): 6 people, 6.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.82%
Nuclear Magnetic Resonance Imaging Abdominal: 6 people, 6.82%
Wheezing (a high-pitched whistling sound made while you breath): 5 people, 5.68%

* Approximation only. Some reports may have incomplete information.

Do you take Plaquenil and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Plaquenil:

Plaquenil (91,018 reports)

Anhedonia treatments and more:

Anhedonia (51,944 reports)

Browse all side effects of Plaquenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,506 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,284 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.