Plaquenil and Fracture nonunion - a phase IV clinical study of FDA data

Summary:

Fracture nonunion is reported as a side effect among people who take Plaquenil (hydroxychloroquine sulfate), especially for people who are female, 40-49 old, have been taking the drug for 10+ years also take Fosamax, and have Osteoporosis.

The phase IV clinical study analyzes which people have Fracture nonunion when taking Plaquenil. It is created by eHealthMe based on reports of 88,348 people who have side effects when taking Plaquenil from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

What is Fracture nonunion?

Fracture nonunion (permanent failure of healing following a broken bone) is found to be associated with 311 drugs and 369 conditions by eHealthMe. Check the latest studies of Fracture nonunion.

On Jul, 23, 2026

88,348 people reported to have side effects when taking Plaquenil.
Among them, 42 people (0.05%) have Fracture nonunion.

Could Plaquenil cause Fracture nonunion?

Among these 42 people:

How long have people been on Plaquenil when they have Fracture nonunion? *

What is the gender of people who have Fracture nonunion when taking Plaquenil? *

female: 97.3 %
male: 2.7 %

What is the age of people who have Fracture nonunion when taking Plaquenil? *

What are other drugs people take besides Plaquenil? *

Fosamax: 34 people, 80.95%
Humira: 16 people, 38.10%
Celebrex: 14 people, 33.33%
Prednisone: 13 people, 30.95%
Methotrexate: 12 people, 28.57%
Synthroid: 11 people, 26.19%
Feldene: 10 people, 23.81%
Flonase: 9 people, 21.43%
Arava: 9 people, 21.43%
Omega-3 Marine Triglycerides: 8 people, 19.05%

What are other side effects people have besides Fracture nonunion? *

Femur Fracture: 34 people, 80.95%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 21 people, 50.00%
Fall: 21 people, 50.00%
High Blood Pressure: 20 people, 47.62%
Pain In Extremity: 18 people, 42.86%
Foot Fracture: 18 people, 42.86%
Fracture Delayed Union (delayed cure of broken bone): 17 people, 40.48%
Dyspnea (difficult or laboured breathing): 15 people, 35.71%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 15 people, 35.71%
Depression: 14 people, 33.33%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 27 people, 64.29%
Osteopenia (a condition where bone mineral density is lower than normal): 10 people, 23.81%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 23.81%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 16.67%
Asthma: 7 people, 16.67%
Hypersensitivity: 7 people, 16.67%
Upper Respiratory Tract Infection: 6 people, 14.29%
Synovitis (inflammation of the synovial membrane): 6 people, 14.29%
High Blood Cholesterol: 6 people, 14.29%
Bone Density Decreased: 2 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Plaquenil and have Fracture nonunion?

- Check whether Fracture nonunion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Plaquenil:

Plaquenil (91,018 reports)

Browse all side effects of Plaquenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fracture nonunion:

Fracture nonunion (311 drugs)

Browse all the conditions that are associated with Fracture nonunion:

Fracture nonunion (369 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.