Vicodin and Splenic infarction - a phase IV clinical study of FDA data

Summary:

Splenic infarction is reported as a side effect among people who take Vicodin (acetaminophen; hydrocodone bitartrate), especially for people who are male, 60+ old, also take Nexium, and have Myelodysplastic syndrome.

The phase IV clinical study analyzes which people have Splenic infarction when taking Vicodin. It is created by eHealthMe based on reports of 59,416 people who have side effects when taking Vicodin from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Splenic infarction?

Splenic infarction (tissue damage of spleen) is found to be associated with 288 drugs and 529 conditions by eHealthMe. Check the latest studies of Splenic infarction.

On Jul, 23, 2026

59,416 people reported to have side effects when taking Vicodin.
Among them, 16 people (0.03%) have Splenic infarction.

Among these 16 people:

What is the gender of people who have Splenic infarction when taking Vicodin? *

female: 50 %
male: 50 %

What is the age of people who have Splenic infarction when taking Vicodin? *

What are other drugs people take besides Vicodin? *

What are other side effects people have besides Splenic infarction? *

Pleural Effusion (water on the lungs): 9 people, 56.25%
Atelectasis (partial or complete collapse of the lung): 9 people, 56.25%
Abdominal Distension: 5 people, 31.25%
Splenomegaly (enlargement of spleen): 5 people, 31.25%
Fever: 5 people, 31.25%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 31.25%
Drug Ineffective: 5 people, 31.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 31.25%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 5 people, 31.25%
Respiratory Distress (difficulty in breathing): 5 people, 31.25%

What are the existing conditions these people have? *

Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 31.25%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 18.75%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 12.50%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 6.25%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Vicodin and have Splenic infarction?

- Check whether Splenic infarction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vicodin:

Vicodin (63,357 reports)

Splenic infarction treatments and more:

Splenic infarction (2,288 reports)

How severe was Splenic infarction and when was it recovered:

Splenic infarction in Vicodin

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Splenic infarction and drugs with ingredients of acetaminophen; hydrocodone bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vicodin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenic infarction:

Splenic infarction (288 drugs)

Browse all the conditions that are associated with Splenic infarction:

Splenic infarction (529 conditions)

Related publications that referenced our studies

Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Vicodin) and Vicodin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.