Plaquenil and Lymphopenia - a phase IV clinical study of FDA data

Summary:

Lymphopenia is reported as a side effect among people who take Plaquenil (hydroxychloroquine sulfate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Benlysta, and have Migraine.

The phase IV clinical study analyzes which people have Lymphopenia when taking Plaquenil. It is created by eHealthMe based on reports of 88,348 people who have side effects when taking Plaquenil from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

What is Lymphopenia?

Lymphopenia (an abnormally low level of lymphocytes in the blood) is found to be associated with 889 drugs and 1,075 conditions by eHealthMe. Check the latest studies of Lymphopenia.

On Jul, 31, 2026

88,348 people reported to have side effects when taking Plaquenil.
Among them, 51 people (0.06%) have Lymphopenia.

Among these 51 people:

How long have people been on Plaquenil when they have Lymphopenia? *

What is the gender of people who have Lymphopenia when taking Plaquenil? *

female: 74.51 %
male: 25.49 %

What is the age of people who have Lymphopenia when taking Plaquenil? *

What are other drugs people take besides Plaquenil? *

What are other side effects people have besides Lymphopenia? *

Leukopenia (less number of white blood cells in blood): 16 people, 31.37%
Jc Virus Infection: 12 people, 23.53%
Progressive Multifocal Leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells): 12 people, 23.53%
Speech Impairment (Adult) (inability to speak (adult)): 12 people, 23.53%
Rashes (redness): 10 people, 19.61%
C-Reactive Protein Increased: 9 people, 17.65%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 9 people, 17.65%
Fever: 9 people, 17.65%
Joint Pain: 9 people, 17.65%
Thrombocytopenia (decrease of platelets in blood): 8 people, 15.69%

What are the existing conditions these people have? *

Migraine (headache): 3 people, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 3.92%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 3.92%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 2 people, 3.92%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 1.96%
Pain: 1 person, 1.96%
Neuropsychiatric Lupus (the various psychiatric and neurologic symptoms due to a multi system inflammatory disorder): 1 person, 1.96%
High Blood Pressure: 1 person, 1.96%
Hepatitis C: 1 person, 1.96%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 1 person, 1.96%

* Approximation only. Some reports may have incomplete information.

Do you take Plaquenil and have Lymphopenia?

- Check whether Lymphopenia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Plaquenil:

Plaquenil (91,018 reports)

Lymphopenia treatments and more:

Lymphopenia (16,935 reports)

Browse all side effects of Plaquenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lymphopenia:

Lymphopenia (889 drugs)

Browse all the conditions that are associated with Lymphopenia:

Lymphopenia (1,075 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.