Plaquenil and Weight bearing difficulty - a phase IV clinical study of FDA data

Summary:

Weight bearing difficulty is reported as a side effect among people who take Plaquenil (hydroxychloroquine sulfate), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Humira, and have Pain.

The phase IV clinical study analyzes which people have Weight bearing difficulty when taking Plaquenil. It is created by eHealthMe based on reports of 88,348 people who have side effects when taking Plaquenil from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,016 Plaquenil users. Check the latest studies of Plaquenil.

What is Weight bearing difficulty?

Weight bearing difficulty (difficulty due to weight of thigh fat deposition) is found to be associated with 337 drugs and 821 conditions by eHealthMe. Check the latest studies of Weight bearing difficulty.

On Apr, 17, 2026

88,348 people reported to have side effects when taking Plaquenil.
Among them, 45 people (0.05%) have Weight bearing difficulty.

Could Plaquenil cause Weight bearing difficulty?

Among these 45 people:

How long have people been on Plaquenil when they have Weight bearing difficulty? *

What is the gender of people who have Weight bearing difficulty when taking Plaquenil? *

female: 88.64 %
male: 11.36 %

What is the age of people who have Weight bearing difficulty when taking Plaquenil? *

What are other drugs people take besides Plaquenil? *

What are other side effects people have besides Weight bearing difficulty? *

Pain In Extremity: 28 people, 62.22%
Joint Pain: 26 people, 57.78%
Pain: 21 people, 46.67%
Joint Swelling: 15 people, 33.33%
Nausea (feeling of having an urge to vomit): 14 people, 31.11%
Drug Ineffective: 13 people, 28.89%
Peripheral Swelling: 12 people, 26.67%
Gait Disturbance: 12 people, 26.67%
Fatigue (feeling of tiredness): 10 people, 22.22%
Fall: 10 people, 22.22%

What are the existing conditions these people have? *

Pain: 10 people, 22.22%
High Blood Cholesterol: 5 people, 11.11%
Depression: 4 people, 8.89%
Neuropathy Peripheral (surface nerve damage): 3 people, 6.67%
Insomnia (sleeplessness): 3 people, 6.67%
High Blood Pressure: 3 people, 6.67%
Diabetes: 2 people, 4.44%
Stress And Anxiety: 2 people, 4.44%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 4.44%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 4.44%

* Approximation only. Some reports may have incomplete information.

Do you take Plaquenil and have Weight bearing difficulty?

- Check whether Weight bearing difficulty is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Plaquenil:

Plaquenil (91,016 reports)

Browse all side effects of Plaquenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight bearing difficulty:

Weight bearing difficulty (337 drugs)

Browse all the conditions that are associated with Weight bearing difficulty:

Weight bearing difficulty (821 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.