Excedrin and Pioglitazone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Pioglitazone (pioglitazone hydrochloride). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Pioglitazone. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

On Jul, 19, 2026

19 people who take Excedrin and Pioglitazone together, and have interactions are studied.

Excedrin and Pioglitazone drug interactions.

What are the common drug interactions of Excedrin and Pioglitazone, by gender? *:

female:

Chronic kidney disease
Depression
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Abdominal distension
Anxiety
Arthralgia (joint pain)
Arthropathy
Asthma
Back pain

male:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nausea (feeling of having an urge to vomit)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Renal failure (kidney dysfunction)
Constipation
Dementia (madness)
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Glaucoma (increased fluid pressure in the eye with vision loss)

What are the common drug interactions of Excedrin and Pioglitazone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Abdominal distension
Anxiety
Constipation
Decreased appetite
Depression
Diarrhoea
Joint injury
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)

50-59:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Arthralgia (joint pain)
Asthma
Back pain
Balance disorder
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cough

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal impairment (severely reduced kidney function)
Thrombosis (formation of a blood clot inside a blood vessel)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Arthropathy
Constipation

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 63.16%
High Blood Pressure: 9 people, 47.37%
Infection: 9 people, 47.37%
Multiple Allergies (allergy to multiple agents): 9 people, 47.37%
Cough: 8 people, 42.11%
Hyperlipidaemia (presence of excess lipids in the blood): 7 people, 36.84%
Hypersensitivity: 7 people, 36.84%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 36.84%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 7 people, 36.84%
Eye Infection: 6 people, 31.58%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and Pioglitazone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously