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Polaramine and Anaphylactoid reaction - a phase IV clinical study of FDA data

Summary:

Anaphylactoid reaction is reported as a side effect among people who take Polaramine (dexchlorpheniramine maleate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Methylprednisolone, and have Breast cancer.

The phase IV clinical study analyzes which people have Anaphylactoid reaction when taking Polaramine. It is created by eHealthMe based on reports of 10,478 people who have side effects when taking Polaramine from the FDA, and is updated regularly.

What is Polaramine?

Polaramine has active ingredients of dexchlorpheniramine maleate. It is often used in allergic rhinitis. eHealthMe is studying from 10,531 Polaramine users. Check the latest studies of Polaramine.

What is Anaphylactoid reaction?

Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation) is found to be associated with 420 drugs and 722 conditions by eHealthMe. Check the latest studies of Anaphylactoid reaction.

On Jul, 07, 2026

10,478 people reported to have side effects when taking Polaramine.
Among them, 49 people (0.47%) have Anaphylactoid reaction.

Could Polaramine cause Anaphylactoid reaction?

Among these 49 people:

How long have people been on Polaramine when they have Anaphylactoid reaction? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Anaphylactoid reaction when taking Polaramine? *

  • female: 41.3 %
  • male: 58.7 %

What is the age of people who have Anaphylactoid reaction when taking Polaramine? *

  • 0-1: 6.52 %
  • 2-9: 2.17 %
  • 10-19: 2.17 %
  • 20-29: 8.7 %
  • 30-39: 8.7 %
  • 40-49: 13.04 %
  • 50-59: 13.04 %
  • 60+: 45.65 %

What are other drugs people take besides Polaramine? *

  1. Methylprednisolone: 7 people, 14.29%
  2. Ondansetron: 5 people, 10.20%
  3. Paracetamol: 4 people, 8.16%
  4. Remicade: 4 people, 8.16%
  5. Taxol: 4 people, 8.16%
  6. Carboplatin: 3 people, 6.12%
  7. Decadron: 3 people, 6.12%
  8. Dexamethasone Sodium Phosphate: 3 people, 6.12%
  9. Oxaliplatin: 3 people, 6.12%
  10. Emla: 3 people, 6.12%

What are other side effects people have besides Anaphylactoid reaction? *

  1. Oxygen Saturation Decreased: 13 people, 26.53%
  2. Rashes (redness): 12 people, 24.49%
  3. Infusion Related Reaction: 10 people, 20.41%
  4. Arrhythmias (irregular heartbeat): 8 people, 16.33%
  5. Dyspnea (difficult or laboured breathing): 8 people, 16.33%
  6. Itching: 7 people, 14.29%
  7. Hypotension (abnormally low blood pressure): 7 people, 14.29%
  8. Malaise (a feeling of general discomfort or uneasiness): 6 people, 12.24%
  9. Chest Pain: 6 people, 12.24%
  10. Fever: 6 people, 12.24%

What are the existing conditions these people have? *

  1. Breast Cancer: 4 people, 8.16%
  2. Squamous Cell Carcinoma (a cancer of a kind of epithelial cell): 3 people, 6.12%
  3. Factor Ix Inhibition (suppression of factor ix): 3 people, 6.12%
  4. Haemorrhage Intracranial (bleeding within the skull): 3 people, 6.12%
  5. Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 3 people, 6.12%
  6. Malignant Melanoma (skin cancer rises from melancytes): 2 people, 4.08%
  7. Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 2 people, 4.08%
  8. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 4.08%
  9. Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 2 people, 4.08%
  10. Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 2 people, 4.08%

* Approximation only. Some reports may have incomplete information.

Do you take Polaramine and have Anaphylactoid reaction?

- Check whether Anaphylactoid reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Polaramine:

Anaphylactoid reaction treatments and more:

How severe was Anaphylactoid reaction and when was it recovered:

Expand to all the drugs that have ingredients of dexchlorpheniramine maleate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Polaramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anaphylactoid reaction:

Browse all the conditions that are associated with Anaphylactoid reaction:

How the study uses the data?

The study uses data from the FDA. It is based on dexchlorpheniramine maleate (the active ingredients of Polaramine) and Polaramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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