Prednisolone and Brain midline shift - a phase IV clinical study of FDA data

Summary:

Brain midline shift is reported as a side effect among people who take Prednisolone (prednisolone), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Depakene, and have Back pain.

The phase IV clinical study analyzes which people have Brain midline shift when taking Prednisolone. It is created by eHealthMe based on reports of 211,370 people who have side effects when taking Prednisolone from the FDA, and is updated regularly.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

What is Brain midline shift?

Brain midline shift is found to be associated with 86 drugs and 214 conditions by eHealthMe. Check the latest studies of Brain midline shift.

On Aug, 13, 2026

211,370 people reported to have side effects when taking Prednisolone.
Among them, 28 people (0.01%) have Brain midline shift.

Could Prednisolone cause Brain midline shift?

Among these 28 people:

How long have people been on Prednisolone when they have Brain midline shift? *

What is the gender of people who have Brain midline shift when taking Prednisolone? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Brain midline shift when taking Prednisolone? *

What are other drugs people take besides Prednisolone? *

What are other side effects people have besides Brain midline shift? *

Depressed Level Of Consciousness: 12 people, 42.86%
Fever: 9 people, 32.14%
Intracranial Pressure Increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid): 9 people, 32.14%
Herpes Zoster: 8 people, 28.57%
Brain Herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull): 8 people, 28.57%
Cerebral Haemorrhage (bleeding within the brain): 8 people, 28.57%
Swallowing Difficulty: 8 people, 28.57%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 8 people, 28.57%
White Blood Cell Count Decreased: 7 people, 25.00%
Immune System Disorder: 7 people, 25.00%

What are the existing conditions these people have? *

Venous Thrombosis Limb (blood clot that forms in a vein in the limb): 7 people, 25.00%
Osteoporosis (bones weak and more likely to break): 7 people, 25.00%
Migraine (headache): 7 people, 25.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 25.00%
Constipation: 7 people, 25.00%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 25.00%
Back Pain: 7 people, 25.00%
Pain: 2 people, 7.14%
Bone Marrow Failure: 1 person, 3.57%
Blood Sodium Decreased: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Prednisolone and have Brain midline shift?

- Check whether Brain midline shift is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prednisolone:

Prednisolone (212,675 reports)

Browse all side effects of Prednisolone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain midline shift:

Brain midline shift (86 drugs)

Browse all the conditions that are associated with Brain midline shift:

Brain midline shift (214 conditions)

Related publications that referenced our studies

Abdullah, D., Mohamed, A. M. F. S., & Liew, A. K. C., "Dentine hypersensitivity-like tooth pain associated with the use of high-dose steroid therapy", Journal of conservative dentistry: JCD, 2018 Jan .
Abdullah, D., Mohamed, A. M. F. S., & Liew, A. K. C., "Dentine hypersensitivity-like tooth pain associated with the use of high-dose steroid therapy", Journal of conservative dentistry: JCD, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on prednisolone (the active ingredients of Prednisolone) and Prednisolone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.