Pregabalin and Foot amputation - a phase IV clinical study of FDA data

Summary:

Foot amputation is reported as a side effect among people who take Pregabalin (pregabalin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Clopidogrel, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Foot amputation when taking Pregabalin. It is created by eHealthMe based on reports of 73,056 people who have side effects when taking Pregabalin from the FDA, and is updated regularly.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,070 Pregabalin users. Check the latest studies of Pregabalin.

What is Foot amputation?

Foot amputation (loss of foot) is found to be associated with 128 drugs and 204 conditions by eHealthMe. Check the latest studies of Foot amputation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

73,056 people reported to have side effects when taking Pregabalin.
Among them, 14 people (0.02%) have Foot amputation.

Among these 14 people:

How long have people been on Pregabalin when they have Foot amputation? *

What is the gender of people who have Foot amputation when taking Pregabalin? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Foot amputation when taking Pregabalin? *

What are other drugs people take besides Pregabalin? *

What are other side effects people have besides Foot amputation? *

Osteomyelitis (infection of bone): 11 people, 78.57%
Necrosis (the death of body tissue): 5 people, 35.71%
Cellulitis (infection under the skin): 5 people, 35.71%
Cough: 5 people, 35.71%
Tendon Rupture (tear of tendon): 4 people, 28.57%
High Blood Pressure: 4 people, 28.57%
Impaired Healing: 4 people, 28.57%
Infection: 4 people, 28.57%
Insomnia (sleeplessness): 4 people, 28.57%
Localised Infection (infection at the single location): 4 people, 28.57%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 35.71%
Staphylococcal Infection (an infection with staphylococcus bacteria): 2 people, 14.29%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 2 people, 14.29%
Clostridial Infection (infectious conditions by clostridium bacteria): 2 people, 14.29%
The Flu (the flu is caused by an influenza virus): 1 person, 7.14%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 7.14%
Osteomyelitis (infection of bone): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Pregabalin and have Foot amputation?

- Check whether Foot amputation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pregabalin:

Pregabalin (74,070 reports)

Foot amputation treatments and more:

Foot amputation (1,761 reports)

Browse all side effects of Pregabalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Foot amputation:

Foot amputation (128 drugs)

Browse all the conditions that are associated with Foot amputation:

Foot amputation (204 conditions)

Related publications that referenced our studies

de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .
de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on pregabalin (the active ingredients of Pregabalin) and Pregabalin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.