Premarin and General symptom - a phase IV clinical study of FDA data

Summary:

General symptom is reported as a side effect among people who take Premarin (estrogens, conjugated), especially for people who are female, 50-59 old, also take Neurontin, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have General symptom when taking Premarin. It is created by eHealthMe based on reports of 98,531 people who have side effects when taking Premarin from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is General symptom?

General symptom is found to be associated with 300 drugs and 401 conditions by eHealthMe. Check the latest studies of General symptom.

On Jul, 18, 2026

98,531 people reported to have side effects when taking Premarin.
Among them, 21 people (0.02%) have General symptom.

Among these 21 people:

What is the gender of people who have General symptom when taking Premarin? *

female: 100 %
male: 0.0 %

What is the age of people who have General symptom when taking Premarin? *

What are other drugs people take besides Premarin? *

What are other side effects people have besides General symptom? *

Pain: 10 people, 47.62%
Headache (pain in head): 9 people, 42.86%
Fatigue (feeling of tiredness): 9 people, 42.86%
Weakness: 9 people, 42.86%
Depression: 9 people, 42.86%
Stress And Anxiety: 8 people, 38.10%
Fall: 8 people, 38.10%
Pain In Extremity: 7 people, 33.33%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 7 people, 33.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 28.57%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 38.10%
High Blood Cholesterol: 2 people, 9.52%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.52%
Asthma: 2 people, 9.52%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 9.52%
Gait Disturbance: 2 people, 9.52%
Stress And Anxiety: 1 person, 4.76%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 4.76%
Breast Cancer: 1 person, 4.76%
Depression: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have General symptom?

- Check whether General symptom is associated with a drug or a condition
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- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premarin:

Premarin (99,630 reports)

General symptom treatments and more:

General symptom (8,196 reports)

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with General symptom:

General symptom (300 drugs)

Browse all the conditions that are associated with General symptom:

General symptom (401 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.