Premphase and Stroke - a phase IV clinical study of FDA data

Summary:

Stroke is reported as a side effect among people who take Premphase (estrogens, conjugated; medroxyprogesterone acetate), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Prempro, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Stroke when taking Premphase. It is created by eHealthMe based on reports of 2,248 people who have side effects when taking Premphase from the FDA, and is updated regularly.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 2,345 drugs and 3,024 conditions by eHealthMe. Check the latest studies of Stroke.

On Apr, 30, 2026

2,248 people reported to have side effects when taking Premphase.
Among them, 38 people (1.69%) have Stroke.

Among these 38 people:

How long have people been on Premphase when they have Stroke? *

What is the gender of people who have Stroke when taking Premphase? *

female: 100 %
male: 0.0 %

What is the age of people who have Stroke when taking Premphase? *

What are other drugs people take besides Premphase? *

Prempro: 18 people, 47.37%
Premarin: 16 people, 42.11%
Provera: 11 people, 28.95%
Activella: 6 people, 15.79%
Vioxx: 6 people, 15.79%
Lipitor: 4 people, 10.53%
Cycrin: 4 people, 10.53%
Plaquenil: 4 people, 10.53%
Medroxyprogesterone Acetate: 3 people, 7.89%
Pravachol: 3 people, 7.89%

What are other side effects people have besides Stroke? *

Thrombosis (formation of a blood clot inside a blood vessel): 8 people, 21.05%
High Blood Pressure: 4 people, 10.53%
Increased Tendency To Bruise (increased tendency to injure the underlying soft tissue or bone): 3 people, 7.89%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 3 people, 7.89%
Areflexia (absence of a reflex): 3 people, 7.89%
Belching (release of gas from the digestive tract): 3 people, 7.89%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 3 people, 7.89%
Confusional State: 3 people, 7.89%
Diverticulum Intestinal (a pouch that is attached to the first part of the small intestine): 3 people, 7.89%
Indigestion: 3 people, 7.89%

What are the existing conditions these people have? *

Vaginal Bleeding Between Periods: 3 people, 7.89%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.89%
High Blood Cholesterol: 3 people, 7.89%
Menopausal Symptoms: 2 people, 5.26%
Vaginal Bleeding: 1 person, 2.63%
Shoulder Pain: 1 person, 2.63%
Ill-Defined Disorder: 1 person, 2.63%
Hot Flush (sudden feelings of heat): 1 person, 2.63%
Headache (pain in head): 1 person, 2.63%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Premphase and have Stroke?

- Check whether Stroke is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premphase:

Premphase (2,262 reports)

Stroke treatments and more:

Stroke (334,634 reports)

How severe was Stroke and when was it recovered:

Stroke in Premphase

Expand to all the drugs that have ingredients of estrogens, conjugated; medroxyprogesterone acetate:

Stroke and drugs with ingredients of estrogens, conjugated; medroxyprogesterone acetate (926 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premphase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke:

Stroke (2,345 drugs)

Browse all the conditions that are associated with Stroke:

Stroke (3,024 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Premphase) and Premphase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.