Prempro and Formication - a phase IV clinical study of FDA data

Summary:

Formication is reported as a side effect among people who take Prempro (estrogens, conjugated; medroxyprogesterone acetate), especially for people who are female, 50-59 old, have been taking the drug for 10+ years also take Fluconazole, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Formication when taking Prempro. It is created by eHealthMe based on reports of 42,607 people who have side effects when taking Prempro from the FDA, and is updated regularly.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,949 Prempro users. Check the latest studies of Prempro.

What is Formication?

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin) is found to be associated with 559 drugs and 917 conditions by eHealthMe. Check the latest studies of Formication.

On Jan, 28, 2026

42,607 people reported to have side effects when taking Prempro.
Among them, 12 people (0.03%) have Formication.

Among these 12 people:

How long have people been on Prempro when they have Formication? *

What is the gender of people who have Formication when taking Prempro? *

female: 100 %
male: 0.0 %

What is the age of people who have Formication when taking Prempro? *

What are other drugs people take besides Prempro? *

What are other side effects people have besides Formication? *

Weakness: 5 people, 41.67%
Pain In Extremity: 5 people, 41.67%
Hemiplegia (paralysis of one side of the body): 4 people, 33.33%
Neuralgia (pain in one or more nerves): 4 people, 33.33%
Dyspnea (difficult or laboured breathing): 4 people, 33.33%
Tendon Pain: 4 people, 33.33%
Periorbital Oedema (swelling around the eyes): 4 people, 33.33%
Presyncope: 4 people, 33.33%
Itching: 3 people, 25.00%
Nausea And Vomiting: 3 people, 25.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Urinary Tract Infection: 1 person, 8.33%
Pain: 1 person, 8.33%
Kidney Infection: 1 person, 8.33%
Infection: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Prempro and have Formication?

- Check whether Formication is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prempro:

Prempro (42,949 reports)

Formication treatments and more:

Formication (8,246 reports)

How severe was Formication and when was it recovered:

Formication in Prempro

Expand to all the drugs that have ingredients of estrogens, conjugated; medroxyprogesterone acetate:

Formication and drugs with ingredients of estrogens, conjugated; medroxyprogesterone acetate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prempro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Formication:

Formication (559 drugs)

Browse all the conditions that are associated with Formication:

Formication (917 conditions)

Drugs similar to Prempro and Formication :

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Prempro) and Prempro (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.