Primaquine and Acute kidney failure - a phase IV clinical study of FDA data

Summary:

Acute kidney failure is reported as a side effect among people who take Primaquine (primaquine phosphate), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Doxycycline, and have Malaria.

The phase IV clinical study analyzes which people have Acute kidney failure when taking Primaquine. It is created by eHealthMe based on reports of 474 people who have side effects when taking Primaquine from the FDA, and is updated regularly.

What is Primaquine?

Primaquine has active ingredients of primaquine phosphate. eHealthMe is studying from 483 Primaquine users. Check the latest studies of Primaquine.

What is Acute kidney failure?

Acute kidney failure is found to be associated with 2,831 drugs and 4,491 conditions by eHealthMe. Check the latest studies of Acute kidney failure.

On Jul, 09, 2026

474 people reported to have side effects when taking Primaquine.
Among them, 12 people (2.53%) have Acute kidney failure.

Could Primaquine cause Acute kidney failure?

Among these 12 people:

How long have people been on Primaquine when they have Acute kidney failure? *

What is the gender of people who have Acute kidney failure when taking Primaquine? *

female: 8.33 %
male: 91.67 %

What is the age of people who have Acute kidney failure when taking Primaquine? *

What are other drugs people take besides Primaquine? *

Doxycycline: 3 people, 25.00%
Tylenol: 2 people, 16.67%
Truvada: 2 people, 16.67%
Sulfamethoxazole And Trimethoprim: 2 people, 16.67%
Lasix: 2 people, 16.67%
Coumadin: 2 people, 16.67%
Zofran: 1 person, 8.33%
Cozaar: 1 person, 8.33%
Chloroquine Phosphate: 1 person, 8.33%
Cleocin: 1 person, 8.33%

What are other side effects people have besides Acute kidney failure? *

Chronic Kidney Disease: 2 people, 16.67%
Myoglobinuria (presence of myoglobin in the urine): 2 people, 16.67%
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood): 2 people, 16.67%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 2 people, 16.67%
Septic Shock (shock due to blood infection): 1 person, 8.33%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 1 person, 8.33%
Cerebral Haemorrhage (bleeding within the brain): 1 person, 8.33%
Diarrhea: 1 person, 8.33%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 1 person, 8.33%
Haemoglobinuria (the presence of free haemoglobin in the urine): 1 person, 8.33%

What are the existing conditions these people have? *

Malaria (a parasitic disease due to mosquito bite): 5 people, 41.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Viral Infection: 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 8.33%
Cytomegalovirus Infection: 1 person, 8.33%
Diarrhea: 1 person, 8.33%
Ependymoma (tumour in the brain): 1 person, 8.33%
Flatulence (flatus expelled through the anus): 1 person, 8.33%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Primaquine and have Acute kidney failure?

- Check whether Acute kidney failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Primaquine:

Primaquine (483 reports)

Browse all side effects of Primaquine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute kidney failure:

Acute kidney failure (2,831 drugs)

Browse all the conditions that are associated with Acute kidney failure:

Acute kidney failure (4,491 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on primaquine phosphate (the active ingredients of Primaquine) and Primaquine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.