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Prinivil and Interstitial nephritis - a phase IV clinical study of FDA data

Summary:

Interstitial nephritis is reported as a side effect among people who take Prinivil (lisinopril), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Nexium, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Interstitial nephritis when taking Prinivil. It is created by eHealthMe based on reports of 19,973 people who have side effects when taking Prinivil from the FDA, and is updated regularly.

What is Prinivil?

Prinivil has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 20,152 Prinivil users. Check the latest studies of Prinivil.

What is Interstitial nephritis?

Interstitial nephritis (inflammation of the kidney) is found to be associated with 1,088 drugs and 1,567 conditions by eHealthMe. Check the latest studies of Interstitial nephritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

19,973 people reported to have side effects when taking Prinivil.
Among them, 66 people (0.33%) have Interstitial nephritis.

Could Prinivil cause Interstitial nephritis?

Among these 66 people:

How long have people been on Prinivil when they have Interstitial nephritis? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 14.29 %
  • 1 - 2 years: 71.43 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 14.29 %
  • 10+ years: 0.0 %

What is the gender of people who have Interstitial nephritis when taking Prinivil? *

  • female: 58.73 %
  • male: 41.27 %

What is the age of people who have Interstitial nephritis when taking Prinivil? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 5.0 %
  • 40-49: 35.0 %
  • 50-59: 18.33 %
  • 60+: 41.67 %

What are other drugs people take besides Prinivil? *

  1. Nexium: 34 people, 51.52%
  2. Protonix: 31 people, 46.97%
  3. Prilosec: 29 people, 43.94%
  4. Nexium 24hr: 23 people, 34.85%
  5. Zantac: 21 people, 31.82%
  6. Prilosec Otc: 21 people, 31.82%
  7. Prevacid: 20 people, 30.30%
  8. Norvasc: 20 people, 30.30%
  9. Vicodin: 16 people, 24.24%
  10. Hydrodiuril: 15 people, 22.73%

What are other side effects people have besides Interstitial nephritis? *

  1. Chronic Kidney Disease: 40 people, 60.61%
  2. Acute Kidney Failure: 38 people, 57.58%
  3. Indigestion: 12 people, 18.18%
  4. Blood Creatinine Increased: 12 people, 18.18%
  5. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue): 11 people, 16.67%
  6. Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 11 people, 16.67%
  7. Inflammatory Marker Increased: 11 people, 16.67%
  8. Intervertebral Discitis (infection in the intervertebral disc space): 11 people, 16.67%
  9. Asymptomatic Bacteriuria (the presence of bacteria in urine not due to contamination from urine sample collection): 11 people, 16.67%
  10. Renal Injury (kidney injury): 11 people, 16.67%

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 27 people, 40.91%
  2. Pain: 20 people, 30.30%
  3. Gastric Ph Decreased: 15 people, 22.73%
  4. Staphylococcal Infection (an infection with staphylococcus bacteria): 11 people, 16.67%
  5. High Blood Cholesterol: 8 people, 12.12%
  6. Depressed Mood: 7 people, 10.61%
  7. Depression: 7 people, 10.61%
  8. Hyperlipidaemia (presence of excess lipids in the blood): 7 people, 10.61%
  9. Indigestion: 6 people, 9.09%
  10. Ulcer Haemorrhage (bleeding ulcer): 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Prinivil and have Interstitial nephritis?

- Check whether Interstitial nephritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prinivil:

Interstitial nephritis treatments and more:

How severe was Interstitial nephritis and when was it recovered:

Expand to all the drugs that have ingredients of lisinopril:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prinivil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interstitial nephritis:

Browse all the conditions that are associated with Interstitial nephritis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisinopril (the active ingredients of Prinivil) and Prinivil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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