Pristiq and Negative thoughts - a phase IV clinical study of FDA data

Summary:

Negative thoughts is reported as a side effect among people who take Pristiq (desvenlafaxine succinate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Effexor Xr, and have Sleep disorder.

The phase IV clinical study analyzes which people have Negative thoughts when taking Pristiq. It is created by eHealthMe based on reports of 15,699 people who have side effects when taking Pristiq from the FDA, and is updated regularly.

What is Pristiq?

Pristiq has active ingredients of desvenlafaxine succinate. It is often used in depression. eHealthMe is studying from 19,555 Pristiq users. Check the latest studies of Pristiq.

What is Negative thoughts?

Negative thoughts is found to be associated with 241 drugs and 407 conditions by eHealthMe. Check the latest studies of Negative thoughts.

On Jul, 09, 2026

15,699 people reported to have side effects when taking Pristiq.
Among them, 48 people (0.31%) have Negative thoughts.

Among these 48 people:

How long have people been on Pristiq when they have Negative thoughts? *

What is the gender of people who have Negative thoughts when taking Pristiq? *

female: 74.47 %
male: 25.53 %

What is the age of people who have Negative thoughts when taking Pristiq? *

What are other drugs people take besides Pristiq? *

What are other side effects people have besides Negative thoughts? *

Insomnia (sleeplessness): 29 people, 60.42%
Apathy: 28 people, 58.33%
Agitation (state of anxiety or nervous excitement): 27 people, 56.25%
Nervousness: 26 people, 54.17%
Crying: 26 people, 54.17%
Fatigue (feeling of tiredness): 25 people, 52.08%
Irritability: 25 people, 52.08%
Weakness: 24 people, 50.00%
Depressed Mood: 24 people, 50.00%
Disturbance In Attention: 23 people, 47.92%

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 8.33%
High Blood Cholesterol: 3 people, 6.25%
Gastric Disorder (disease of stomach): 3 people, 6.25%
Back Pain: 3 people, 6.25%
Bipolar Disorder (mood disorder): 2 people, 4.17%
Mood Swings (an extreme or rapid change in mood): 1 person, 2.08%
Irritable Bowel Syndrome: 1 person, 2.08%
Irritability: 1 person, 2.08%
Insomnia (sleeplessness): 1 person, 2.08%
High Blood Pressure: 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Pristiq and have Negative thoughts?

- Check whether Negative thoughts is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pristiq:

Pristiq (19,555 reports)

Browse all side effects of Pristiq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Negative thoughts:

Negative thoughts (241 drugs)

Browse all the conditions that are associated with Negative thoughts:

Negative thoughts (407 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on desvenlafaxine succinate (the active ingredients of Pristiq) and Pristiq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.