Proctofoam hc and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Proctofoam hc (hydrocortisone acetate; pramoxine hydrochloride), especially for people who are male, 30-39 old, also take Atrovent, and have Cataplexy.

The phase IV clinical study analyzes which people have Depression when taking Proctofoam hc. It is created by eHealthMe based on reports of 548 people who have side effects when taking Proctofoam hc from the FDA, and is updated regularly.

What is Proctofoam hc?

Proctofoam hc has active ingredients of hydrocortisone acetate; pramoxine hydrochloride. It is often used in hemorrhoids. eHealthMe is studying from 555 Proctofoam hc users. Check the latest studies of Proctofoam hc.

What is Depression?

Depression is found to be associated with 3,169 drugs and 4,130 conditions by eHealthMe. Check the latest studies of Depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

548 people reported to have side effects when taking Proctofoam hc.
Among them, 17 people (3.1%) have Depression.

Among these 17 people:

What is the gender of people who have Depression when taking Proctofoam hc? *

female: 35.71 %
male: 64.29 %

What is the age of people who have Depression when taking Proctofoam hc? *

What are other drugs people take besides Proctofoam hc? *

Xyrem: 4 people, 23.53%
Motrin: 4 people, 23.53%
Viagra: 4 people, 23.53%
Oxycodone And Acetaminophen: 4 people, 23.53%
Atrovent: 4 people, 23.53%
Suprax: 3 people, 17.65%
Ibuprofen: 3 people, 17.65%
Amoxicillin: 3 people, 17.65%
Atripla: 3 people, 17.65%
Abilify: 2 people, 11.76%

What are other side effects people have besides Depression? *

Stress And Anxiety: 10 people, 58.82%
Chronic Kidney Disease: 7 people, 41.18%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 5 people, 29.41%
Intervertebral Disc Degeneration (spinal disc degeneration): 5 people, 29.41%
Headache (pain in head): 5 people, 29.41%
Suicidal Ideation: 5 people, 29.41%
Mood Swings (an extreme or rapid change in mood): 4 people, 23.53%
Post-Traumatic Stress Disorder: 4 people, 23.53%
Tinnitus (a ringing in the ears): 4 people, 23.53%
Pain: 3 people, 17.65%

What are the existing conditions these people have? *

Quit Smoking: 3 people, 17.65%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 17.65%
Hiv Infection: 3 people, 17.65%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 17.65%
Psychotic Disorder: 2 people, 11.76%
Stress And Anxiety: 1 person, 5.88%
Streptococcal Infection: 1 person, 5.88%
Pain: 1 person, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.88%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Proctofoam hc and have Depression?

- Check whether Depression is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Proctofoam hc:

Proctofoam hc (555 reports)

Depression treatments and more:

Depression (652,162 reports)

How severe was Depression and when was it recovered:

Depression in Proctofoam hc

Expand to all the drugs that have ingredients of hydrocortisone acetate; pramoxine hydrochloride:

Depression and drugs with ingredients of hydrocortisone acetate; pramoxine hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Proctofoam hc:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,169 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,130 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone acetate; pramoxine hydrochloride (the active ingredients of Proctofoam hc) and Proctofoam hc (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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