Profen and Foot amputation - a phase IV clinical study of FDA data

Summary:

Foot amputation is reported as a side effect among people who take Profen (ibuprofen), especially for people who are female, 60+ old, also take Metformin, and have Chronic obstructive pulmonary disease.

The phase IV clinical study analyzes which people have Foot amputation when taking Profen. It is created by eHealthMe based on reports of 239,319 people who have side effects when taking Profen from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Foot amputation?

Foot amputation (loss of foot) is found to be associated with 128 drugs and 204 conditions by eHealthMe. Check the latest studies of Foot amputation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

239,319 people reported to have side effects when taking Profen.
Among them, 11 people (0.0%) have Foot amputation.

Among these 11 people:

What is the gender of people who have Foot amputation when taking Profen? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Foot amputation when taking Profen? *

What are other drugs people take besides Profen? *

What are other side effects people have besides Foot amputation? *

Headache (pain in head): 5 people, 45.45%
Joint Pain: 4 people, 36.36%
Skin Ulcer: 4 people, 36.36%
Fever: 3 people, 27.27%
Fatigue (feeling of tiredness): 3 people, 27.27%
Localised Infection (infection at the single location): 3 people, 27.27%
Staphylococcal Infection (an infection with staphylococcus bacteria): 2 people, 18.18%
Dyspnea (difficult or laboured breathing): 2 people, 18.18%
Osteomyelitis (infection of bone): 2 people, 18.18%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 2 people, 18.18%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 18.18%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 18.18%
Wound: 1 person, 9.09%
Thrombocytopenic Purpura (a bleeding disorder in which the immune system destroys platelets): 1 person, 9.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
Klinefelter's Syndrome (a chromosomal abnormality (xxy)weaker muscles and reduced strength): 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%
Ill-Defined Disorder: 1 person, 9.09%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 9.09%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and have Foot amputation?

- Check whether Foot amputation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Profen:

Profen (245,311 reports)

Foot amputation treatments and more:

Foot amputation (1,761 reports)

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Foot amputation:

Foot amputation (128 drugs)

Browse all the conditions that are associated with Foot amputation:

Foot amputation (204 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Profen) and Profen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.