Profen and Hypophysitis - a phase IV clinical study of FDA data

Summary:

Hypophysitis is reported as a side effect among people who take Profen (ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Tylenol, and have Metastatic malignant melanoma.

The phase IV clinical study analyzes which people have Hypophysitis when taking Profen. It is created by eHealthMe based on reports of 239,319 people who have side effects when taking Profen from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,298 Profen users. Check the latest studies of Profen.

What is Hypophysitis?

Hypophysitis (inflammation of the pituitary gland) is found to be associated with 190 drugs and 169 conditions by eHealthMe. Check the latest studies of Hypophysitis.

On Aug, 20, 2025

239,319 people reported to have side effects when taking Profen.
Among them, 32 people (0.01%) have Hypophysitis.

Among these 32 people:

How long have people been on Profen when they have Hypophysitis? *

What is the gender of people who have Hypophysitis when taking Profen? *

female: 58.06 %
male: 41.94 %

What is the age of people who have Hypophysitis when taking Profen? *

What are other drugs people take besides Profen? *

What are other side effects people have besides Hypophysitis? *

Headache (pain in head): 4 people, 12.50%
Diarrhea: 3 people, 9.38%
Blood Testosterone Decreased: 3 people, 9.38%
Blood Cortisol Decreased: 3 people, 9.38%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 6.25%
Dizziness: 2 people, 6.25%
Dehydration (dryness resulting from the removal of water): 2 people, 6.25%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 2 people, 6.25%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 2 people, 6.25%
Chorioretinopathy (collection of fluid under the retina that results in visual distortion): 2 people, 6.25%

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 11 people, 34.38%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 11 people, 34.38%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 12.50%
Renal Cell Carcinoma (a kidney cancer): 3 people, 9.38%
Headache (pain in head): 3 people, 9.38%
Weight Loss: 2 people, 6.25%
Blepharitis (chronic inflammation of the eyelid): 2 people, 6.25%
Diabetes: 2 people, 6.25%
Diarrhea: 2 people, 6.25%
Fungal Nail Infection: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and have Hypophysitis?

- Check whether Hypophysitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Profen:

Profen (245,298 reports)

Hypophysitis treatments and more:

Hypophysitis (2,640 reports)

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypophysitis:

Hypophysitis (190 drugs)

Browse all the conditions that are associated with Hypophysitis:

Hypophysitis (169 conditions)

Drugs similar to Profen and Hypophysitis :

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Profen) and Profen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.