Profen and Injection site scar - a phase IV clinical study of FDA data

Summary:

Injection site scar is reported as a side effect among people who take Profen (ibuprofen), especially for people who are female, 50-59 old, also take Rebif, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Injection site scar when taking Profen. It is created by eHealthMe based on reports of 239,319 people who have side effects when taking Profen from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Injection site scar?

Injection site scar is found to be associated with 209 drugs and 254 conditions by eHealthMe. Check the latest studies of Injection site scar.

On Jul, 03, 2026

239,319 people reported to have side effects when taking Profen.
Among them, 37 people (0.02%) have Injection site scar.

Among these 37 people:

What is the gender of people who have Injection site scar when taking Profen? *

female: 75.68 %
male: 24.32 %

What is the age of people who have Injection site scar when taking Profen? *

What are other drugs people take besides Profen? *

What are other side effects people have besides Injection site scar? *

Injection Site Pain: 15 people, 40.54%
Fatigue (feeling of tiredness): 14 people, 37.84%
Injection Site Erythema (redness at injection site): 13 people, 35.14%
Injection Site Discoloration: 7 people, 18.92%
Injection Site Swelling: 7 people, 18.92%
Influenza Like Illness: 6 people, 16.22%
Stress And Anxiety: 6 people, 16.22%
Injection Site Pruritus (severe itching at injection site): 6 people, 16.22%
Injection Site Mass: 6 people, 16.22%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 6 people, 16.22%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 19 people, 51.35%
Stress And Anxiety: 5 people, 13.51%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 10.81%
Depression: 4 people, 10.81%
Heart Rate Irregular: 4 people, 10.81%
Joint Pain: 4 people, 10.81%
Migraine (headache): 4 people, 10.81%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 4 people, 10.81%
Gastric Ulcer (stomach ulcer): 3 people, 8.11%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and have Injection site scar?

- Check whether Injection site scar is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Profen:

Profen (245,311 reports)

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site scar:

Injection site scar (209 drugs)

Browse all the conditions that are associated with Injection site scar:

Injection site scar (254 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Profen) and Profen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.