Profen and Intervertebral discitis - a phase IV clinical study of FDA data

Summary:

Intervertebral discitis is reported as a side effect among people who take Profen (ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Intervertebral discitis when taking Profen. It is created by eHealthMe based on reports of 239,319 people who have side effects when taking Profen from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Intervertebral discitis?

Intervertebral discitis (infection in the intervertebral disc space) is found to be associated with 259 drugs and 330 conditions by eHealthMe. Check the latest studies of Intervertebral discitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

239,319 people reported to have side effects when taking Profen.
Among them, 58 people (0.02%) have Intervertebral discitis.

Could Profen cause Intervertebral discitis?

Among these 58 people:

How long have people been on Profen when they have Intervertebral discitis? *

What is the gender of people who have Intervertebral discitis when taking Profen? *

female: 50.88 %
male: 49.12 %

What is the age of people who have Intervertebral discitis when taking Profen? *

What are other drugs people take besides Profen? *

What are other side effects people have besides Intervertebral discitis? *

Osteomyelitis (infection of bone): 14 people, 24.14%
Gait Disturbance: 12 people, 20.69%
Sepsis (a severe blood infection that can lead to organ failure and death): 9 people, 15.52%
Infection: 7 people, 12.07%
Intervertebral Disc Protrusion (spinal disc protrusion): 7 people, 12.07%
Extradural Abscess (pus may gather between a patient's skull and his dura): 7 people, 12.07%
Staphylococcal Infection (an infection with staphylococcus bacteria): 7 people, 12.07%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 7 people, 12.07%
Fatigue (feeling of tiredness): 6 people, 10.34%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 6 people, 10.34%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 17.24%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 15.52%
Depression: 6 people, 10.34%
High Blood Pressure: 6 people, 10.34%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 6.90%
Neck Pain: 4 people, 6.90%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 6.90%
Asthma: 4 people, 6.90%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 6.90%
Stress And Anxiety: 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and have Intervertebral discitis?

- Check whether Intervertebral discitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Profen:

Profen (245,311 reports)

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral discitis:

Intervertebral discitis (259 drugs)

Browse all the conditions that are associated with Intervertebral discitis:

Intervertebral discitis (330 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Profen) and Profen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.