Profen and Transfusion-related acute lung injury - a phase IV clinical study of FDA data

Summary:

Transfusion-related acute lung injury is reported as a side effect among people who take Profen (ibuprofen), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Acetaminophen, and have Influenza like illness.

The phase IV clinical study analyzes which people have Transfusion-related acute lung injury when taking Profen. It is created by eHealthMe based on reports of 239,319 people who have side effects when taking Profen from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

What is Transfusion-related acute lung injury?

Transfusion-related acute lung injury (lung injury due to blood transfusion) is found to be associated with 30 drugs and 168 conditions by eHealthMe. Check the latest studies of Transfusion-related acute lung injury.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

239,319 people reported to have side effects when taking Profen.
Among them, 13 people (0.01%) have Transfusion-related acute lung injury.

Could Profen cause Transfusion-related acute lung injury?

Among these 13 people:

How long have people been on Profen when they have Transfusion-related acute lung injury? *

What is the gender of people who have Transfusion-related acute lung injury when taking Profen? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Transfusion-related acute lung injury when taking Profen? *

What are other drugs people take besides Profen? *

What are other side effects people have besides Transfusion-related acute lung injury? *

Acute Hepatic Failure: 9 people, 69.23%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 9 people, 69.23%
Dermatitis Exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss): 8 people, 61.54%
Pneumonia: 8 people, 61.54%
Pulmonary Oedema (fluid accumulation in the lungs): 7 people, 53.85%
Encephalopathy (functioning of the brain is affected by some agent or condition): 6 people, 46.15%
Purpura (purplish discoloration of the skin): 4 people, 30.77%
Haemorrhagic Diathesis (bleeding tendency): 4 people, 30.77%
Pleural Effusion (water on the lungs): 4 people, 30.77%
Renal Impairment (severely reduced kidney function): 4 people, 30.77%

What are the existing conditions these people have? *

Influenza Like Illness: 6 people, 46.15%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 5 people, 38.46%
Gastroenteritis (inflammation of stomach and intestine): 4 people, 30.77%
Lymph Node Pain: 2 people, 15.38%
Immunodeficiency: 2 people, 15.38%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 2 people, 15.38%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 7.69%
Skin Haemorrhage (bleeding into skin): 1 person, 7.69%
Kawasaki's Disease (an autoimmune disease in which the medium-sized blood vessels throughout the body become inflamed): 1 person, 7.69%
International Normalised Ratio Increased: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and have Transfusion-related acute lung injury?

- Check whether Transfusion-related acute lung injury is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Profen:

Profen (245,312 reports)

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Transfusion-related acute lung injury:

Transfusion-related acute lung injury (30 drugs)

Browse all the conditions that are associated with Transfusion-related acute lung injury:

Transfusion-related acute lung injury (168 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Profen) and Profen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.