Progesterone and Adrenal insufficiency - a phase IV clinical study of FDA data

Summary:

Adrenal insufficiency is reported as a side effect among people who take Progesterone (progesterone), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Adrenal insufficiency when taking Progesterone. It is created by eHealthMe based on reports of 20,008 people who have side effects when taking Progesterone from the FDA, and is updated regularly.

What is Progesterone?

Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,021 Progesterone users. Check the latest studies of Progesterone.

What is Adrenal insufficiency?

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids) is found to be associated with 967 drugs and 1,093 conditions by eHealthMe. Check the latest studies of Adrenal insufficiency.

On Jul, 16, 2026

20,008 people reported to have side effects when taking Progesterone.
Among them, 21 people (0.1%) have Adrenal insufficiency.

Could Progesterone cause Adrenal insufficiency?

Among these 21 people:

How long have people been on Progesterone when they have Adrenal insufficiency? *

What is the gender of people who have Adrenal insufficiency when taking Progesterone? *

female: 100 %
male: 0.0 %

What is the age of people who have Adrenal insufficiency when taking Progesterone? *

What are other drugs people take besides Progesterone? *

Prednisone: 5 people, 23.81%
Xyrem: 5 people, 23.81%
Tylenol: 4 people, 19.05%
Solu-Medrol: 4 people, 19.05%
Terbinafine Hydrochloride: 4 people, 19.05%
Benadryl: 4 people, 19.05%
Wellbutrin: 3 people, 14.29%
Prozac: 3 people, 14.29%
Calcium: 3 people, 14.29%
Cymbalta: 2 people, 9.52%

What are other side effects people have besides Adrenal insufficiency? *

Weight Decreased: 7 people, 33.33%
Pain: 5 people, 23.81%
Cervical Polyp (tumour on the surface of the cervical canal): 4 people, 19.05%
Hyperhidrosis (abnormally increased sweating): 4 people, 19.05%
Depressed Mood: 4 people, 19.05%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 4 people, 19.05%
Drug Hypersensitivity: 4 people, 19.05%
Dyspnea (difficult or laboured breathing): 3 people, 14.29%
Skin Discoloration: 3 people, 14.29%
Stress And Anxiety: 3 people, 14.29%

What are the existing conditions these people have? *

Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 4 people, 19.05%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 19.05%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 14.29%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 9.52%
Stress And Anxiety: 1 person, 4.76%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 4.76%
Blood Pressure Abnormal: 1 person, 4.76%
Cushing's Syndrome (obesity, a rounded face, increased fat): 1 person, 4.76%
Disturbance In Attention: 1 person, 4.76%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Progesterone and have Adrenal insufficiency?

- Check whether Adrenal insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Progesterone:

Progesterone (21,021 reports)

Browse all side effects of Progesterone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal insufficiency:

Adrenal insufficiency (967 drugs)

Browse all the conditions that are associated with Adrenal insufficiency:

Adrenal insufficiency (1,093 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on progesterone (the active ingredients of Progesterone) and Progesterone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.