Prolia and Calciphylaxis - a phase IV clinical study of FDA data

Summary:

Calciphylaxis is reported as a side effect among people who take Prolia (denosumab), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Lyrica, and have Rickets.

The phase IV clinical study analyzes which people have Calciphylaxis when taking Prolia. It is created by eHealthMe based on reports of 150,727 people who have side effects when taking Prolia from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,384 Prolia users. Check the latest studies of Prolia.

What is Calciphylaxis?

Calciphylaxis (is a syndrome with vascular calcium accumulation) is found to be associated with 139 drugs and 382 conditions by eHealthMe. Check the latest studies of Calciphylaxis.

On Feb, 04, 2026

150,727 people reported to have side effects when taking Prolia.
Among them, 10 people (0.01%) have Calciphylaxis.

Among these 10 people:

How long have people been on Prolia when they have Calciphylaxis? *

What is the gender of people who have Calciphylaxis when taking Prolia? *

female: 88.89 %
male: 11.11 %

What is the age of people who have Calciphylaxis when taking Prolia? *

What are other drugs people take besides Prolia? *

What are other side effects people have besides Calciphylaxis? *

Urinary Tract Infection: 2 people, 20.00%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 2 people, 20.00%
Bacterial Infection: 2 people, 20.00%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 2 people, 20.00%
Oral Candidiasis (fungal infection of mouth): 2 people, 20.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 10.00%
Haemorrhoidal Haemorrhage (bleeding from the haemorrhoids): 1 person, 10.00%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 10.00%
Fall: 1 person, 10.00%

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 20.00%
Rickets (softening of bones): 2 people, 20.00%
Prostate Cancer: 1 person, 10.00%
Productive Cough: 1 person, 10.00%
Infection: 1 person, 10.00%
Haemorrhage (bleeding): 1 person, 10.00%
Blood Pressure Abnormal: 1 person, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Prolia and have Calciphylaxis?

- Check whether Calciphylaxis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prolia:

Prolia (151,384 reports)

Calciphylaxis treatments and more:

Calciphylaxis (2,031 reports)

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Calciphylaxis:

Calciphylaxis (139 drugs)

Browse all the conditions that are associated with Calciphylaxis:

Calciphylaxis (382 conditions)

Drugs similar to Prolia and Calciphylaxis :

How the study uses the data?

The study uses data from the FDA. It is based on denosumab (the active ingredients of Prolia) and Prolia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.