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Prolia and Mitral valve incompetence - a phase IV clinical study of FDA data

Summary:

Mitral valve incompetence is reported as a side effect among people who take Prolia (denosumab), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Calcium, and have Pain.

The phase IV clinical study analyzes which people have Mitral valve incompetence when taking Prolia. It is created by eHealthMe based on reports of 150,727 people who have side effects when taking Prolia from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,389 Prolia users. Check the latest studies of Prolia.

What is Mitral valve incompetence?

Mitral valve incompetence (inefficient heart valve) is found to be associated with 1,431 drugs and 1,280 conditions by eHealthMe. Check the latest studies of Mitral valve incompetence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

150,727 people reported to have side effects when taking Prolia.
Among them, 38 people (0.03%) have Mitral valve incompetence.

Could Prolia cause Mitral valve incompetence?

Among these 38 people:

How long have people been on Prolia when they have Mitral valve incompetence? *

  • < 1 month: 33.33 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

What is the gender of people who have Mitral valve incompetence when taking Prolia? *

  • female: 97.22 %
  • male: 2.78 %

What is the age of people who have Mitral valve incompetence when taking Prolia? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 12.12 %
  • 60+: 87.88 %

What are other drugs people take besides Prolia? *

  1. Calcium: 8 people, 21.05%
  2. Vitamin D3: 6 people, 15.79%
  3. Crestor: 5 people, 13.16%
  4. Vitamin B12: 5 people, 13.16%
  5. Proair Hfa: 4 people, 10.53%
  6. Plavix: 3 people, 7.89%
  7. Aspirin: 3 people, 7.89%
  8. Vitamin C: 3 people, 7.89%
  9. Amlodipine: 3 people, 7.89%
  10. Omeprazole: 3 people, 7.89%

What are other side effects people have besides Mitral valve incompetence? *

  1. Tricuspid Valve Incompetence (inefficient heart valve): 11 people, 28.95%
  2. Fatigue (feeling of tiredness): 10 people, 26.32%
  3. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 26.32%
  4. Weakness: 8 people, 21.05%
  5. Aortic Valve Incompetence: 7 people, 18.42%
  6. Dyspnea (difficult or laboured breathing): 6 people, 15.79%
  7. Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 15.79%
  8. Nausea (feeling of having an urge to vomit): 6 people, 15.79%
  9. Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 6 people, 15.79%
  10. Rickets (softening of bones): 6 people, 15.79%

What are the existing conditions these people have? *

  1. Pain: 5 people, 13.16%
  2. High Blood Pressure: 4 people, 10.53%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 7.89%
  4. Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 2 people, 5.26%
  5. Breast Cancer Metastatic: 2 people, 5.26%
  6. Diarrhea: 2 people, 5.26%
  7. Dementia (madness): 2 people, 5.26%
  8. Cardiac Failure Congestive: 2 people, 5.26%
  9. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 2 people, 5.26%
  10. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Prolia and have Mitral valve incompetence?

- Check whether Mitral valve incompetence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prolia:

Mitral valve incompetence treatments and more:

How severe was Mitral valve incompetence and when was it recovered:

Expand to all the drugs that have ingredients of denosumab:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mitral valve incompetence:

Browse all the conditions that are associated with Mitral valve incompetence:

How the study uses the data?

The study uses data from the FDA. It is based on denosumab (the active ingredients of Prolia) and Prolia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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