Propofol and Subcutaneous emphysema - a phase IV clinical study of FDA data

Summary:

Subcutaneous emphysema is reported as a side effect among people who take Propofol (propofol), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Midazolam, and have Asthma.

The phase IV clinical study analyzes which people have Subcutaneous emphysema when taking Propofol. It is created by eHealthMe based on reports of 37,986 people who have side effects when taking Propofol from the FDA, and is updated regularly.

What is Propofol?

Propofol has active ingredients of propofol. It is often used in colonoscopy abnormal. eHealthMe is studying from 38,224 Propofol users. Check the latest studies of Propofol.

What is Subcutaneous emphysema?

Subcutaneous emphysema (smooth bulging of the skin) is found to be associated with 171 drugs and 524 conditions by eHealthMe. Check the latest studies of Subcutaneous emphysema.

On Jul, 17, 2026

37,986 people reported to have side effects when taking Propofol.
Among them, 38 people (0.1%) have Subcutaneous emphysema.

Could Propofol cause Subcutaneous emphysema?

Among these 38 people:

How long have people been on Propofol when they have Subcutaneous emphysema? *

What is the gender of people who have Subcutaneous emphysema when taking Propofol? *

female: 45.95 %
male: 54.05 %

What is the age of people who have Subcutaneous emphysema when taking Propofol? *

What are other drugs people take besides Propofol? *

Midazolam: 11 people, 28.95%
Ondansetron: 10 people, 26.32%
Fentanyl: 6 people, 15.79%
Heparin: 3 people, 7.89%
Piperacillin And Tazobactam: 3 people, 7.89%
Xylocaine: 3 people, 7.89%
Paracetamol: 3 people, 7.89%
Cefazolin: 3 people, 7.89%
Humalog: 2 people, 5.26%
Levemir: 2 people, 5.26%

What are other side effects people have besides Subcutaneous emphysema? *

Pneumomediastinum (air is present in the mediastinum): 13 people, 34.21%
Pneumoperitoneum (air or gas in the abdominal (peritoneal) cavity): 6 people, 15.79%
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung): 6 people, 15.79%
Tracheal Injury (injury to trachea): 5 people, 13.16%
Procedural Vomiting: 5 people, 13.16%
Procedural Nausea: 5 people, 13.16%
Dyspnea (difficult or laboured breathing): 5 people, 13.16%
Ear Barotrauma (discomfort and possible damage in the ear due to pressure differences between the inside and outside of the eardrum): 4 people, 10.53%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 4 people, 10.53%
Pulmonary Air Leakage: 4 people, 10.53%

What are the existing conditions these people have? *

Asthma: 5 people, 13.16%
Sedation: 4 people, 10.53%
General Anaesthesia: 3 people, 7.89%
High Blood Pressure: 2 people, 5.26%
Pneumonia: 2 people, 5.26%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 5.26%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 1 person, 2.63%
Alkalosis: 1 person, 2.63%
Anaesthetic Complication Vascular (complications of anaesthesia following major vascular surgery): 1 person, 2.63%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Propofol and have Subcutaneous emphysema?

- Check whether Subcutaneous emphysema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Propofol:

Propofol (38,224 reports)

Browse all side effects of Propofol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Subcutaneous emphysema:

Subcutaneous emphysema (171 drugs)

Browse all the conditions that are associated with Subcutaneous emphysema:

Subcutaneous emphysema (524 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on propofol (the active ingredients of Propofol) and Propofol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.