Protease and Cough - a phase IV clinical study of FDA data

Summary:

Cough is reported as a side effect among people who take Protease (papain), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Norco, and have Osteoporosis.

The phase IV clinical study analyzes which people have Cough when taking Protease. It is created by eHealthMe based on reports of 175 people who have side effects when taking Protease from the FDA, and is updated regularly.

What is Protease?

Protease has active ingredients of papain. eHealthMe is studying from 182 Protease users. Check the latest studies of Protease.

What is Cough?

Cough is found to be associated with 3,050 drugs and 3,801 conditions by eHealthMe. Check the latest studies of Cough.

On Jul, 19, 2026

175 people reported to have side effects when taking Protease.
Among them, 14 people (8.0%) have Cough.

Among these 14 people:

How long have people been on Protease when they have Cough? *

What is the gender of people who have Cough when taking Protease? *

female: 70 %
male: 30 %

What is the age of people who have Cough when taking Protease? *

What are other drugs people take besides Protease? *

What are other side effects people have besides Cough? *

Headache (pain in head): 10 people, 71.43%
Weakness: 10 people, 71.43%
Insomnia (sleeplessness): 10 people, 71.43%
Joint Pain: 10 people, 71.43%
Dyspnea (difficult or laboured breathing): 10 people, 71.43%
Nausea (feeling of having an urge to vomit): 10 people, 71.43%
White Blood Cell Count Increased: 9 people, 64.29%
Fever: 9 people, 64.29%
Hepatic Steatosis (fatty liver disease): 7 people, 50.00%
Hepatic Cyst: 7 people, 50.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 7 people, 50.00%
Hepatitis C: 3 people, 21.43%
Diabetes: 3 people, 21.43%
Insomnia (sleeplessness): 3 people, 21.43%
Skin Ulcer: 3 people, 21.43%
Facial Pain: 1 person, 7.14%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1 person, 7.14%
Anaemia (lack of blood): 1 person, 7.14%
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 1 person, 7.14%
Diarrhea: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Protease and have Cough?

- Check whether Cough is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protease:

Protease (182 reports)

Cough treatments and more:

Cough (361,791 reports)

Browse all side effects of Protease:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cough:

Cough (3,050 drugs)

Browse all the conditions that are associated with Cough:

Cough (3,801 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on papain (the active ingredients of Protease) and Protease (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.