Protopic and Flushing - a phase IV clinical study of FDA data

Summary:

Flushing is reported as a side effect among people who take Protopic (tacrolimus), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humira, and have Dermatitis atopic.

The phase IV clinical study analyzes which people have Flushing when taking Protopic. It is created by eHealthMe based on reports of 5,328 people who have side effects when taking Protopic from the FDA, and is updated regularly.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

What is Flushing?

Flushing (the warm, red condition of human skin) is found to be associated with 2,045 drugs and 2,904 conditions by eHealthMe. Check the latest studies of Flushing.

On Jan, 30, 2026

5,328 people reported to have side effects when taking Protopic.
Among them, 27 people (0.51%) have Flushing.

Among these 27 people:

How long have people been on Protopic when they have Flushing? *

What is the gender of people who have Flushing when taking Protopic? *

female: 74.07 %
male: 25.93 %

What is the age of people who have Flushing when taking Protopic? *

What are other drugs people take besides Protopic? *

Calcipotriene And Betamethasone Dipropionate: 7 people, 25.93%
Cosentyx: 7 people, 25.93%
Humira: 7 people, 25.93%
Acitretin: 3 people, 11.11%
Alcohol: 3 people, 11.11%
Calcitriol: 3 people, 11.11%
Dupixent: 3 people, 11.11%
Methotrexate: 3 people, 11.11%
Singulair: 2 people, 7.41%
Cymbalta: 2 people, 7.41%

What are other side effects people have besides Flushing? *

Sinus Congestion (blockage of sinus): 9 people, 33.33%
Chest Pain: 8 people, 29.63%
Fatigue (feeling of tiredness): 8 people, 29.63%
Viral Infection: 7 people, 25.93%
Nasopharyngitis (inflammation of the nasopharynx): 7 people, 25.93%
Inflammation: 7 people, 25.93%
Infectious Thyroiditis (inflammation of the thyroid gland due to infection): 7 people, 25.93%
High Blood Pressure: 7 people, 25.93%
Urticaria (rash of round, red welts on the skin that itch intensely): 7 people, 25.93%
Fungal Infection: 7 people, 25.93%

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 5 people, 18.52%
Rosacea (a skin condition that causes facial redness): 2 people, 7.41%
Depression: 2 people, 7.41%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 1 person, 3.70%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 3.70%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 3.70%
Inflammation: 1 person, 3.70%
Ill-Defined Disorder: 1 person, 3.70%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 3.70%
Hiv Infection: 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Protopic and have Flushing?

- Check whether Flushing is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protopic:

Protopic (5,403 reports)

Flushing treatments and more:

Flushing (117,675 reports)

Browse all side effects of Protopic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flushing:

Flushing (2,045 drugs)

Browse all the conditions that are associated with Flushing:

Flushing (2,904 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Protopic) and Protopic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.