Provera and Left ventricular dysfunction - a phase IV clinical study of FDA data

Summary:

Left ventricular dysfunction is reported as a side effect among people who take Provera (medroxyprogesterone acetate), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Premarin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Left ventricular dysfunction when taking Provera. It is created by eHealthMe based on reports of 53,365 people who have side effects when taking Provera from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,941 Provera users. Check the latest studies of Provera.

What is Left ventricular dysfunction?

Left ventricular dysfunction is found to be associated with 952 drugs and 784 conditions by eHealthMe. Check the latest studies of Left ventricular dysfunction.

On Oct, 27, 2025

53,365 people reported to have side effects when taking Provera.
Among them, 26 people (0.05%) have Left ventricular dysfunction.

Could Provera cause Left ventricular dysfunction?

Among these 26 people:

How long have people been on Provera when they have Left ventricular dysfunction? *

What is the gender of people who have Left ventricular dysfunction when taking Provera? *

female: 96.15 %
male: 3.85 %

What is the age of people who have Left ventricular dysfunction when taking Provera? *

What are other drugs people take besides Provera? *

What are other side effects people have besides Left ventricular dysfunction? *

Fatigue (feeling of tiredness): 18 people, 69.23%
Chest Pain: 17 people, 65.38%
Fainting (loss of consciousness and postural tone): 16 people, 61.54%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 15 people, 57.69%
Stress And Anxiety: 15 people, 57.69%
Pain: 15 people, 57.69%
Gallstones (stone formation by bile component): 15 people, 57.69%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 14 people, 53.85%
High Blood Pressure: 14 people, 53.85%
Mitral Valve Incompetence (inefficient heart valve): 14 people, 53.85%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 9 people, 34.62%
Osteopenia (a condition where bone mineral density is lower than normal): 8 people, 30.77%
Menopausal Symptoms: 4 people, 15.38%
Hot Flush (sudden feelings of heat): 3 people, 11.54%
Menopause (end of monthly cycles in women): 2 people, 7.69%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 7.69%
High Blood Pressure: 2 people, 7.69%
High Blood Cholesterol: 2 people, 7.69%
Breast Cancer Metastatic: 2 people, 7.69%
Menstruation Irregular: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Provera and have Left ventricular dysfunction?

- Check whether Left ventricular dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Provera:

Provera (54,941 reports)

Browse all side effects of Provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (952 drugs)

Browse all the conditions that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (784 conditions)

Drugs similar to Provera and Left ventricular dysfunction :

Related publications that referenced our studies

Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Provera) and Provera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.