Pyrazinamide and Liver function test abnormal - a phase IV clinical study of FDA data

Summary:

Liver function test abnormal is reported as a side effect among people who take Pyrazinamide (pyrazinamide), especially for people who are male, 40-49 old, have been taking the drug for 1 - 6 months also take Isoniazid, and have Psoriasis.

The phase IV clinical study analyzes which people have Liver function test abnormal when taking Pyrazinamide. It is created by eHealthMe based on reports of 10,019 people who have side effects when taking Pyrazinamide from the FDA, and is updated regularly.

What is Pyrazinamide?

Pyrazinamide has active ingredients of pyrazinamide. It is often used in tuberculosis. eHealthMe is studying from 10,062 Pyrazinamide users. Check the latest studies of Pyrazinamide.

What is Liver function test abnormal?

Liver function test abnormal is found to be associated with 1,536 drugs and 1,944 conditions by eHealthMe. Check the latest studies of Liver function test abnormal.

On Sep, 23, 2025

10,019 people reported to have side effects when taking Pyrazinamide.
Among them, 110 people (1.1%) have Liver function test abnormal.

Could Pyrazinamide cause Liver function test abnormal?

Among these 110 people:

How long have people been on Pyrazinamide when they have Liver function test abnormal? *

What is the gender of people who have Liver function test abnormal when taking Pyrazinamide? *

female: 30.19 %
male: 69.81 %

What is the age of people who have Liver function test abnormal when taking Pyrazinamide? *

What are other drugs people take besides Pyrazinamide? *

Isoniazid: 31 people, 28.18%
Rifampin: 14 people, 12.73%
Erelzi: 9 people, 8.18%
Enbrel: 8 people, 7.27%
Ethambutol Hydrochloride: 7 people, 6.36%
Methotrexate: 6 people, 5.45%
Myambutol: 5 people, 4.55%
Sulfasalazine: 4 people, 3.64%
Premarin: 4 people, 3.64%
Folic Acid: 4 people, 3.64%

What are other side effects people have besides Liver function test abnormal? *

Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 62 people, 56.36%
Hepatotoxicity (chemical-driven liver damage): 42 people, 38.18%
Hepatic Failure (liver failure): 41 people, 37.27%
Encephalopathy (functioning of the brain is affected by some agent or condition): 20 people, 18.18%
Ascites (accumulation of fluid in the abdominal cavity): 20 people, 18.18%
Blood Creatinine Increased: 20 people, 18.18%
Drug Ineffective: 19 people, 17.27%
Splenomegaly (enlargement of spleen): 19 people, 17.27%
Pneumonia: 19 people, 17.27%
Sepsis (a severe blood infection that can lead to organ failure and death): 18 people, 16.36%

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 18 people, 16.36%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 17 people, 15.45%
Ankylosing Spondylitis (type of arthritis affecting the spine): 16 people, 14.55%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 9 people, 8.18%
Hiv Infection: 8 people, 7.27%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 4.55%
Pulmonary Tuberculosis (lungs tuberculosis): 4 people, 3.64%
Lymph Node Tuberculosis: 4 people, 3.64%
Burkitt Lymphoma (cancer of the lymphatic system): 1 person, 0.91%
Choroid Tubercles (tuberculosis of eye): 1 person, 0.91%

* Approximation only. Some reports may have incomplete information.

Do you take Pyrazinamide and have Liver function test abnormal?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pyrazinamide:

Pyrazinamide (10,062 reports)

Common Pyrazinamide side effects:

Browse all side effects of Pyrazinamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Liver function test abnormal:

Browse all the drugs that are associated with Liver function test abnormal:

Liver function test abnormal (1,536 drugs)

Common conditions associated with Liver function test abnormal:

Ra: 3,254 reports
Ms: 1,865 reports
Hypertension: 1,439 reports
Blood pressure - high: 1,423 reports
Lipid disorders: 1,376 reports
Lipoprotein test: 1,344 reports
Pain: 1,285 reports
Primary pulmonary hypertension: 1,264 reports
Antidepressant therapy: 1,173 reports
Reduce cholesterol: 1,162 reports

Browse all the conditions that are associated with Liver function test abnormal:

Liver function test abnormal (1,944 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pyrazinamide (the active ingredients of Pyrazinamide) and Pyrazinamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.