Rapamune and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Rapamune (sirolimus), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Bactrim, and have Immunodeficiency disorders.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Rapamune. It is created by eHealthMe based on reports of 13,732 people who have side effects when taking Rapamune from the FDA, and is updated regularly.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,347 drugs and 1,692 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

On Jul, 14, 2026

13,732 people reported to have side effects when taking Rapamune.
Among them, 36 people (0.26%) have Aseptic necrosis.

Among these 36 people:

How long have people been on Rapamune when they have Aseptic necrosis? *

What is the gender of people who have Aseptic necrosis when taking Rapamune? *

female: 34.29 %
male: 65.71 %

What is the age of people who have Aseptic necrosis when taking Rapamune? *

What are other drugs people take besides Rapamune? *

What are other side effects people have besides Aseptic necrosis? *

Fever: 6 people, 16.67%
High Blood Pressure: 5 people, 13.89%
Joint Pain: 5 people, 13.89%
Diarrhea: 4 people, 11.11%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 8.33%
Dehydration (dryness resulting from the removal of water): 3 people, 8.33%
Muscle Atrophy (a decrease in the mass of the muscle): 2 people, 5.56%
Mucous Stools (mucous with stool): 2 people, 5.56%
Memory Loss: 2 people, 5.56%
Localised Infection (infection at the single location): 2 people, 5.56%

What are the existing conditions these people have? *

Immunodeficiency Disorders: 5 people, 13.89%
Transplant Rejection (a transplant material is not worked): 3 people, 8.33%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 3 people, 8.33%
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 2 people, 5.56%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 5.56%
Device Related Infection: 2 people, 5.56%
Goodpasture's Syndrome (immune system mistakenly attacks and destroys healthy body tissue): 2 people, 5.56%
High Blood Cholesterol: 2 people, 5.56%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 2 people, 5.56%
Osteoporosis (bones weak and more likely to break): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Rapamune and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rapamune:

Rapamune (13,848 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Rapamune:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,347 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,692 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sirolimus (the active ingredients of Rapamune) and Rapamune (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.