Rayaldee and Weakness - a phase IV clinical study of FDA data

Summary:

Weakness is reported as a side effect among people who take Rayaldee (calcifediol), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Fluoxetine Hydrochloride, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Weakness when taking Rayaldee. It is created by eHealthMe based on reports of 340 people who have side effects when taking Rayaldee from the FDA, and is updated regularly.

What is Rayaldee?

Rayaldee has active ingredients of calcifediol. eHealthMe is studying from 342 Rayaldee users. Check the latest studies of Rayaldee.

What is Weakness?

Weakness is found to be associated with 3,642 drugs and 6,611 conditions by eHealthMe. Check the latest studies of Weakness.

On Apr, 18, 2026

340 people reported to have side effects when taking Rayaldee.
Among them, 16 people (4.71%) have Weakness.

Among these 16 people:

How long have people been on Rayaldee when they have Weakness? *

What is the gender of people who have Weakness when taking Rayaldee? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Weakness when taking Rayaldee? *

What are other drugs people take besides Rayaldee? *

Hydrocodone Bitartrate And Acetaminophen: 5 people, 31.25%
Montelukast Sodium: 5 people, 31.25%
Allopurinol: 5 people, 31.25%
Amoxicillin And Clavulanate Potassium: 5 people, 31.25%
Divalproex Sodium: 5 people, 31.25%
Epinephrine: 5 people, 31.25%
Ergocalciferol: 5 people, 31.25%
Euthyrox: 5 people, 31.25%
Flecainide Acetate: 5 people, 31.25%
Fluoxetine Hydrochloride: 5 people, 31.25%

What are other side effects people have besides Weakness? *

Fatigue (feeling of tiredness): 7 people, 43.75%
Fall: 7 people, 43.75%
Weight Increased: 6 people, 37.50%
Chronic Kidney Disease: 5 people, 31.25%
Urinary Tract Infection: 5 people, 31.25%
Nausea And Vomiting: 5 people, 31.25%
Headache (pain in head): 5 people, 31.25%
Fever: 5 people, 31.25%
Oxygen Saturation Decreased: 5 people, 31.25%
Pharyngitis Streptococcal (inflammation of the pharynx caused by infection from. streptococcus): 5 people, 31.25%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 31.25%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 3 people, 18.75%
Secondary Hyperthyroidism: 2 people, 12.50%
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium): 2 people, 12.50%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 2 people, 12.50%
Swelling: 1 person, 6.25%
Rickets (softening of bones): 1 person, 6.25%
Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 1 person, 6.25%
Multiple Myeloma (cancer of the plasma cells): 1 person, 6.25%
Chronic Kidney Disease: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Rayaldee and have Weakness?

- Check whether Weakness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rayaldee:

Rayaldee (342 reports)

Weakness treatments and more:

Weakness (586,876 reports)

Browse all side effects of Rayaldee:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weakness:

Weakness (3,642 drugs)

Browse all the conditions that are associated with Weakness:

Weakness (6,611 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on calcifediol (the active ingredients of Rayaldee) and Rayaldee (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.