1. Home
  2. Analysis
  3. Requip
  4. Extrapyramidal-disorder

Requip and Extrapyramidal disorder - a phase IV clinical study of FDA data

Summary:

Extrapyramidal disorder is reported as a side effect among people who take Requip (ropinirole hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Metoclopramide, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Extrapyramidal disorder when taking Requip. It is created by eHealthMe based on reports of 21,866 people who have side effects when taking Requip from the FDA, and is updated regularly.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

What is Extrapyramidal disorder?

Extrapyramidal disorder (involuntary muscle spasms in the face and neck) is found to be associated with 813 drugs and 960 conditions by eHealthMe. Check the latest studies of Extrapyramidal disorder.

On Jul, 14, 2026

21,866 people reported to have side effects when taking Requip.
Among them, 65 people (0.3%) have Extrapyramidal disorder.

Could Requip cause Extrapyramidal disorder?

Among these 65 people:

How long have people been on Requip when they have Extrapyramidal disorder? *

  • < 1 month: 66.67 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Extrapyramidal disorder when taking Requip? *

  • female: 79.66 %
  • male: 20.34 %

What is the age of people who have Extrapyramidal disorder when taking Requip? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 5.41 %
  • 40-49: 5.41 %
  • 50-59: 27.03 %
  • 60+: 62.16 %

What are other drugs people take besides Requip? *

  1. Metoclopramide: 23 people, 35.38%
  2. Mirapex: 11 people, 16.92%
  3. Levaquin: 10 people, 15.38%
  4. Lipitor: 10 people, 15.38%
  5. Hydrochlorothiazide: 10 people, 15.38%
  6. Neurontin: 10 people, 15.38%
  7. Lisinopril: 9 people, 13.85%
  8. Xanax: 9 people, 13.85%
  9. Omeprazole: 8 people, 12.31%
  10. Prilosec: 8 people, 12.31%

What are other side effects people have besides Extrapyramidal disorder? *

  1. Tardive Dyskinesia (a disorder that involves involuntary movements): 27 people, 41.54%
  2. Tremor (trembling or shaking movements in one or more parts of your body): 24 people, 36.92%
  3. Dyskinesia (abnormality or impairment of voluntary movement): 15 people, 23.08%
  4. Emotional Disorder: 15 people, 23.08%
  5. Injury: 14 people, 21.54%
  6. Stress And Anxiety: 14 people, 21.54%
  7. Pain: 13 people, 20.00%
  8. Nausea (feeling of having an urge to vomit): 12 people, 18.46%
  9. Nervous System Disorder (a general class of medical conditions affecting the nervous system): 11 people, 16.92%
  10. Weakness: 11 people, 16.92%

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 12.31%
  2. Abdominal Pain: 3 people, 4.62%
  3. Nausea (feeling of having an urge to vomit): 3 people, 4.62%
  4. Bipolar Disorder (mood disorder): 2 people, 3.08%
  5. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 3.08%
  6. Breast Cancer: 2 people, 3.08%
  7. Indigestion: 2 people, 3.08%
  8. Impaired Gastric Emptying: 2 people, 3.08%
  9. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 3.08%
  10. Diabetic Gastroparesis (paralysis of the muscles of the stomach caused by diabetes): 1 person, 1.54%

* Approximation only. Some reports may have incomplete information.

Do you take Requip and have Extrapyramidal disorder?

- Check whether Extrapyramidal disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Requip:

Extrapyramidal disorder treatments and more:

How severe was Extrapyramidal disorder and when was it recovered:

Expand to all the drugs that have ingredients of ropinirole hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Requip:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Extrapyramidal disorder:

Browse all the conditions that are associated with Extrapyramidal disorder:

How the study uses the data?

The study uses data from the FDA. It is based on ropinirole hydrochloride (the active ingredients of Requip) and Requip (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.