Restasis and Ra - a phase IV clinical study of FDA data

Summary:

Ra is reported as a side effect among people who take Restasis (cyclosporine), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Humira, and have Pain.

The phase IV clinical study analyzes which people have Ra when taking Restasis. It is created by eHealthMe based on reports of 34,716 people who have side effects when taking Restasis from the FDA, and is updated regularly.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.

What is Ra?

Ra (rheumatoid arthritis) is found to be associated with 1,613 drugs and 2,087 conditions by eHealthMe. Check the latest studies of Ra.

On Aug, 31, 2025

34,716 people reported to have side effects when taking Restasis.
Among them, 550 people (1.58%) have Ra.

Among these 550 people:

How long have people been on Restasis when they have Ra? *

What is the gender of people who have Ra when taking Restasis? *

female: 94.6 %
male: 5.4 %

What is the age of people who have Ra when taking Restasis? *

What are other drugs people take besides Restasis? *

What are other side effects people have besides Ra? *

Herpes Zoster: 231 people, 42.00%
Drug Ineffective: 218 people, 39.64%
Joint Pain: 176 people, 32.00%
Pain: 157 people, 28.55%
Fatigue (feeling of tiredness): 142 people, 25.82%
Joint Swelling: 142 people, 25.82%
Rashes (redness): 134 people, 24.36%
Drug Hypersensitivity: 131 people, 23.82%
Tenderness (pain or discomfort when an affected area is touched): 127 people, 23.09%
Oral Pain: 126 people, 22.91%

What are the existing conditions these people have? *

Pain: 67 people, 12.18%
Eye Disorder: 54 people, 9.82%
Dizziness: 53 people, 9.64%
Thyroid Diseases: 52 people, 9.45%
Joint Pain: 42 people, 7.64%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 27 people, 4.91%
High Blood Cholesterol: 22 people, 4.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 22 people, 4.00%
Asthma: 19 people, 3.45%
High Blood Pressure: 18 people, 3.27%

* Approximation only. Some reports may have incomplete information.

Do you take Restasis and have Ra?

- Check whether Ra is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Restasis:

Restasis (35,199 reports)

Ra treatments and more:

Ra (1,091,818 reports)

Common Restasis side effects:

Browse all side effects of Restasis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ra:

Enbrel side effect: Ra (61,655 reports)
Methotrexate side effect: Ra (61,185 reports)
Humira side effect: Ra (46,149 reports)
Prednisone side effect: Ra (35,759 reports)
Orencia side effect: Ra (31,786 reports)
Actemra side effect: Ra (30,529 reports)
Sulfasalazine side effect: Ra (27,331 reports)
Xeljanz side effect: Ra (26,067 reports)
Arava side effect: Ra (24,240 reports)
Remicade side effect: Ra (24,072 reports)

Browse all the drugs that are associated with Ra:

Ra (1,613 drugs)

Common conditions associated with Ra:

Ra: 63,567 reports
Rheumatoid arthritis: 63,498 reports
Rheumatoid arthritis aggravated: 31,122 reports
Arthritis - rheumatoid: 29,398 reports
Psoriatic arthropathy aggravated: 4,771 reports
Pain: 4,748 reports
Alternative medicine - pain relief: 4,737 reports
Hypertension: 3,683 reports
Htn: 3,680 reports
Psoriasis: 3,347 reports

Browse all the conditions that are associated with Ra:

Ra (2,087 conditions)

Related publications that referenced our studies

O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on cyclosporine (the active ingredients of Restasis) and Restasis (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.